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Related Experiment Video

Updated: May 24, 2026

A Human Ex Vivo Atherosclerotic Plaque Model to Study Lesion Biology
05:51

A Human Ex Vivo Atherosclerotic Plaque Model to Study Lesion Biology

Published on: May 6, 2014

Inflammation, atherosclerosis, and psoriasis.

David Siegel1, Sridevi Devaraj, Anupam Mitra

  • 1Medical Service, Department of Veterans Affairs, Northern California Health Care System, Mather, CA, USA. david.siegel@va.gov

Clinical Reviews in Allergy & Immunology
|February 24, 2012
PubMed
Summary
This summary is machine-generated.

Inflammation plays a key role in atherosclerosis and cardiovascular events. Psoriasis patients have higher cardiovascular risk due to chronic inflammation and elevated C-reactive protein (CRP) levels.

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A Mouse Model for Pathogen-induced Chronic Inflammation at Local and Systemic Sites
09:52

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Published on: August 8, 2014

Related Experiment Videos

Last Updated: May 24, 2026

A Human Ex Vivo Atherosclerotic Plaque Model to Study Lesion Biology
05:51

A Human Ex Vivo Atherosclerotic Plaque Model to Study Lesion Biology

Published on: May 6, 2014

A Mouse Model for Pathogen-induced Chronic Inflammation at Local and Systemic Sites
09:52

A Mouse Model for Pathogen-induced Chronic Inflammation at Local and Systemic Sites

Published on: August 8, 2014

Area of Science:

  • Cardiovascular Medicine
  • Immunology
  • Dermatology

Background:

  • Inflammation is integral to all stages of atherosclerosis, from initial fatty streaks to acute coronary syndromes.
  • Numerous inflammatory biomarkers, including C-reactive protein (CRP), predict cardiovascular disease (CVD) events.
  • Psoriasis, a chronic inflammatory condition, is linked to increased atherosclerosis and CVD risk, with patients experiencing shorter life expectancy.

Purpose of the Study:

  • To explore the role of inflammation and specific biomarkers in atherosclerosis.
  • To investigate the association between psoriasis and increased CVD risk.
  • To highlight the need for CVD risk factor screening and management in psoriasis patients.

Main Methods:

  • Review of evidence linking inflammation to atherosclerosis and CVD.
  • Analysis of studies on inflammatory biomarkers such as high-sensitivity CRP.
  • Examination of research on psoriasis as a risk factor for atherosclerosis and CVD.

Main Results:

  • Elevated levels of inflammatory biomarkers, particularly high-sensitivity CRP, consistently predict CVD events.
  • Toll-like receptors and lipoprotein-associated phospholipase A2 are implicated in atherosclerosis.
  • Psoriasis patients exhibit chronic inflammation, elevated CRP, and a significantly increased risk of CVD, including coronary artery disease and stroke.

Conclusions:

  • Inflammation is a critical driver of atherosclerosis and cardiovascular events.
  • Psoriasis patients represent an emerging high-risk population for CVD due to associated chronic inflammation.
  • Aggressive screening and treatment of CVD risk factors are recommended for individuals with moderate to severe psoriasis.