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Epigenetic Regulation

Epigenetic Regulation

Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...

Epigenetic Regulation

Epigenetic Regulation

Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.

Abnormal Proliferation

Abnormal Proliferation

Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the daughter...

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Updated: May 24, 2026

Methyl-binding DNA capture Sequencing for Patient Tissues

Methyl-binding DNA capture Sequencing for Patient Tissues

Published on: October 31, 2016

DNA methylation changes in prostate cancer.

Wolfgang Goering¹, Michael Kloth, Wolfgang A Schulz

¹Department of Urology, Heinrich Heine University, Duesseldorf, Germany.

Methods in Molecular Biology (Clifton, N.J.)

|February 24, 2012

Summary

This summary is machine-generated.

DNA methylation alterations are key in prostate cancer development. These epigenetic changes offer potential biomarkers for early detection and identifying aggressive cancer cases.

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Last Updated: May 24, 2026

Methyl-binding DNA capture Sequencing for Patient Tissues

Methyl-binding DNA capture Sequencing for Patient Tissues

Published on: October 31, 2016

miRNA Expression Analyses in Prostate Cancer Clinical Tissues

miRNA Expression Analyses in Prostate Cancer Clinical Tissues

Published on: September 8, 2015

Continuous Fluorescence-Based Endonuclease-Coupled DNA Methylation Assay to Screen for DNA Methyltransferase Inhibitors

Continuous Fluorescence-Based Endonuclease-Coupled DNA Methylation Assay to Screen for DNA Methyltransferase Inhibitors

Published on: August 5, 2022

Area of Science:

Oncology
Epigenetics
Molecular Biology

Background:

Prostate cancer is a leading malignancy in men, with epigenetic alterations playing a crucial role in its development and progression.
DNA methylation is a significant epigenetic mechanism implicated in various cancers, including prostate cancer.

Purpose of the Study:

To review recent research on DNA methylation alterations in prostate cancer.
To highlight the potential of these alterations as biomarkers for prostate cancer detection and prognosis.

Main Methods:

Review of existing scientific literature on DNA methylation in prostate cancer.
Analysis of studies employing both candidate gene approaches and genome-wide screening techniques.

Main Results:

Consistent hypermethylation of genes like GSTP1 occurs during prostate cancer progression, showing promise as a detection biomarker.
Aberrant DNA methylation is associated with diminished gene expression and can identify more aggressive prostate cancer cases.
Genome-wide screening methods are increasingly used, yielding promising results in identifying novel methylation alterations.

Conclusions:

DNA methylation alterations are critical in prostate cancer carcinogenesis and progression.
Hypermethylation events serve as valuable biomarkers for prostate cancer detection and predicting disease aggressiveness.
Emerging genome-wide techniques are advancing the understanding of epigenetic dysregulation in prostate cancer.