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Related Concept Videos

Epigenetic Regulation01:37

Epigenetic Regulation

Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
Epigenetic Regulation01:46

Epigenetic Regulation

Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
Differentiation of Common Myeloid Progenitor Cells01:15

Differentiation of Common Myeloid Progenitor Cells

Common myeloid progenitors (CMPs) are oligopotent cells that can differentiate into granulocytes and macrophages. Granulocytes and macrophages are essential for protecting the body against bacterial, viral, or fungal infections. They migrate from the bone marrow into the circulating blood to reach specific tissue sites where they differentiate and help in immune surveillance. However, they survive only for a few days and must be continuously made available to the organism to maintain a robust...
Abnormal Proliferation02:23

Abnormal Proliferation

Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the daughter...
Genomic Imprinting and Inheritance02:30

Genomic Imprinting and Inheritance

Diploid organisms inherit genetic material through chromosomes from both parents. Copies of the same gene are known as alleles. In most cases, both alleles are simultaneously expressed and allow various cellular processes to function optimally. If one of the alleles is missing or mutated, the expression of the other allele can compensate; however, this is not true for all genes.
The expression of some genes depends on which parent passed the gene to the offspring, through a phenomenon known as...
Induced Pluripotent Stem Cells01:06

Induced Pluripotent Stem Cells

Stem cells are undifferentiated cells that divide and produce different cell types. Ordinarily, cells that have differentiated into a specific cell type are terminally differentiated; however, scientists have found a way to reprogram these mature cells so that they dedifferentiate and return to an unspecialized, proliferative state. These cells are pluripotent like embryonic stem cells—able to produce all cell types—and are called induced pluripotent stem cells (iPSCs).
Somatic cells are...

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Related Experiment Video

Updated: May 24, 2026

Proliferation and Differentiation of Murine Myeloid Precursor 32D/G-CSF-R Cells
10:21

Proliferation and Differentiation of Murine Myeloid Precursor 32D/G-CSF-R Cells

Published on: February 21, 2018

Epigenetics in myeloid malignancies.

Stefan Deneberg1

  • 1Center of Hematology, Karolinska University Hospital, Huddinge, Sweden. stefan.deneberg@ki.se

Methods in Molecular Biology (Clifton, N.J.)
|February 24, 2012
PubMed
Summary

Epigenetic changes are well-studied in myeloid malignancies like acute myeloid leukemia (AML) and myelodysplastic syndromes (MDS). Understanding these epigenetic alterations is crucial for developing targeted epigenetic therapies.

Area of Science:

  • Hematology
  • Cancer epigenetics
  • Molecular oncology

Background:

  • Myeloid hematological malignancies are extensively studied at the epigenetic level.
  • Limited chromosomal abnormalities and genetic mutations facilitate linking epigenetic states to disease.
  • Bone marrow aspiration provides accessible malignant cells, accelerating research.

Purpose of the Study:

  • To describe epigenetic changes in acute myeloid leukemia (AML), chronic myeloid leukemia (CML), and myelodysplastic syndromes (MDS).
  • To provide an overview of the clinical relevance of these epigenetic alterations.
  • To discuss current and future epigenetic therapeutic approaches in myeloid malignancies.

Main Methods:

  • Review of existing literature on epigenetic modifications in myeloid cancers.

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  • Analysis of epigenetic states in relation to genetic and chromosomal abnormalities.
  • Examination of clinical data and therapeutic outcomes related to epigenetic therapies.

    • Main Results:

    • Epigenetic alterations are common and well-characterized in AML, CML, and MDS.
    • The clinical and pathogenetic significance of many epigenetic changes remains under investigation.
    • Demethylating agents like azacitidine represent a successful epigenetic therapy for high-risk MDS.

    Conclusions:

    • Epigenetic research in myeloid malignancies is rapidly advancing due to new analytical techniques.
    • Targeted epigenetic therapies hold significant promise for treating myeloid hematological neoplasms.
    • Further research is needed to fully elucidate the clinical relevance and therapeutic potential of epigenetic modifications.