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Related Concept Videos

Genomics02:02

Genomics

Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...
Reporter Genes02:11

Reporter Genes

Reporter genes are a type of protein-coding gene that are often tagged to a gene of interest. Once inside a target cell, reporter genes usually produce visually identifiable characteristics like fluorescence and luminescence when expressed along with the gene of interest. Thus, reporter genes “report” the presence or absence of genes of interest in an organism, determine the gene expression pattern, or track the physical location of a DNA segment or protein in the cell.
Commonly used reporter...
Genetic Screens02:46

Genetic Screens

Genetic screens are tools used to identify genes and mutations responsible for phenotypes of interest. Genetic screens help identify individuals or a group of people at risk of developing  genetic diseases and help them with early intervention, targeted therapy, and reproductive options.
Forward genetic screens
Forward or “classical” genetic screens involve creating random mutations in an organism’s DNA using radiation, mutagens, or insertion of additional bases, which result in visible changes...
Lampbrush Chromosomes01:51

Lampbrush Chromosomes

In 1882, Flemming observed lampbrush chromosomes (LBC) in salamander eggs. Later in 1892, Rückert observed LBCs in shark egg cells and coined the term "lampbrush chromosomes" because they looked like brushes used to clean kerosene lamps.
LBCs are made up of two pairs of conjugating homologous chromatids. Each chromatid consists of alternatively positioned regions of condensed-inactive chromatin and loosely placed-active side loops, which can be contracted and extended. The loops resemble the...
Lampbrush Chromosomes01:51

Lampbrush Chromosomes

In 1882, Flemming observed lampbrush chromosomes (LBC) in salamander eggs. Later in 1892, Rückert observed LBCs in shark egg cells and coined the term "lampbrush chromosomes" because they looked like brushes used to clean kerosene lamps.
LBCs are made up of two pairs of conjugating homologous chromatids. Each chromatid consists of alternatively positioned regions of condensed-inactive chromatin and loosely placed-active side loops, which can be contracted and extended. The loops resemble the...
Evolutionary Relationships through Genome Comparisons02:54

Evolutionary Relationships through Genome Comparisons

Genome comparison is one of the excellent ways to interpret the evolutionary relationships between organisms. The basic principle of genome comparison is that if two species share a common feature, it is likely encoded by the DNA sequence conserved between both species. The advent of genome sequencing technologies in the late 20th century enabled scientists to understand the concept of conservation of domains between species and helped them to deduce evolutionary relationships across diverse...

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Related Experiment Video

Updated: May 24, 2026

Introductory Analysis and Validation of CUT&#38;RUN Sequencing Data
04:58

Introductory Analysis and Validation of CUT&RUN Sequencing Data

Published on: December 13, 2024

Geno viewer, a SAM/BAM viewer tool.

Miklós Laczik, Edit Tukacs, Béla Uzonyi

    Bioinformation
    |February 24, 2012
    PubMed
    Summary

    Researchers can now efficiently process and visualize Next Generation Sequencing (NGS) data with GenoViewer, a user-friendly tool for SAM/BAM viewing and alignment. This open-source software facilitates customized analysis and data exploration for various NGS tasks.

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    A Deep-sequencing-assisted, Spontaneous Suppressor Screen in the Fission Yeast Schizosaccharomyces pombe

    Published on: March 7, 2019

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    Last Updated: May 24, 2026

    Introductory Analysis and Validation of CUT&#38;RUN Sequencing Data
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    Introductory Analysis and Validation of CUT&RUN Sequencing Data

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    A Deep-sequencing-assisted, Spontaneous Suppressor Screen in the Fission Yeast Schizosaccharomyces pombe
    07:55

    A Deep-sequencing-assisted, Spontaneous Suppressor Screen in the Fission Yeast Schizosaccharomyces pombe

    Published on: March 7, 2019

    Area of Science:

    • Bioinformatics
    • Computational Biology
    • Genomics

    Background:

    • Next Generation Sequencing (NGS) technologies necessitate advanced data processing and visualization methods.
    • Existing tools may not fully address the diverse needs of researchers and service providers in NGS data analysis.

    Purpose of the Study:

    • To develop a user-friendly and efficient software tool for Next Generation Sequencing (NGS) data processing and visualization.
    • To provide a versatile platform for SAM/BAM viewing, alignment, and read mapping.

    Main Methods:

    • Development of GenoViewer, a SAM/BAM viewer and aligner tool.
    • Incorporation of a user-friendly interface for easy operation.
    • Design with a simple architecture for extensibility and customization.

    Main Results:

    • GenoViewer enables fast and efficient browsing, analysis, and read mapping of NGS assemblies.
    • The tool is highly customizable for a wide range of NGS-related tasks.
    • The software's open-source nature allows for specialized visualization functionalities and custom modifications.

    Conclusions:

    • GenoViewer offers a practical solution for enhancing NGS data analysis workflows.
    • The tool's flexibility and ease of use support customized data exploration for researchers.
    • The freely available source code promotes collaborative development and adaptation for specific research needs.