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Related Experiment Video

Updated: May 24, 2026

Mouse Embryonic Lung Culture, A System to Evaluate the Molecular Mechanisms of Branching
07:32

Mouse Embryonic Lung Culture, A System to Evaluate the Molecular Mechanisms of Branching

Published on: June 30, 2010

Branch mode selection during early lung development.

Denis Menshykau1, Conradin Kraemer, Dagmar Iber

  • 1Department for Biosystems Science and Engineering, ETH Zurich, Basel, Switzerland.

Plos Computational Biology
|February 24, 2012
PubMed
Summary
This summary is machine-generated.

Lung branching morphogenesis is a complex process. A new model shows the fibroblast growth factor (FGF10)-sonic hedgehog (SHH)-patched (Ptc) signaling network can generate observed branching patterns.

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Related Experiment Videos

Last Updated: May 24, 2026

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Area of Science:

  • Developmental Biology
  • Systems Biology
  • Computational Biology

Background:

  • Organogenesis involves complex branching morphogenesis, crucial for function.
  • Lung development exhibits stereotyped branching patterns regulated by signaling networks.
  • Existing knowledge lacks an integrated understanding of lung branching regulatory networks.

Purpose of the Study:

  • To develop a deterministic model of the core signaling network governing lung branching morphogenesis.
  • To investigate the role of fibroblast growth factor (FGF10) and sonic hedgehog (SHH) signaling in lung branching.
  • To reproduce experimental observations in wildtype and mutant mice using a computational model.

Main Methods:

  • Developed a spatio-temporal differential-equation based model.
  • Focused on the FGF10, SHH, and Ptc signaling pathway.
  • Utilized a Schnakenberg-type Turing patterning mechanism.
  • Incorporated experimental data for kinetic parameters and domain shape.

Main Results:

  • The model successfully reproduces experimental observations of lung branching patterns in silico.
  • Demonstrated that the FGF10-SHH-Ptc1 module can generate patterns corresponding to observed branching modes.
  • Showed the model's robustness to parameter variations and identified regulatory potential for switching branching modes.
  • Suggested growth speed differences may influence the sequence of branching events.

Conclusions:

  • The FGF10-SHH-Ptc1 signaling module is sufficient to generate patterns underlying lung branching morphogenesis.
  • The model provides a framework for understanding the integrated regulatory network controlling lung development.
  • This systems biology approach offers insights into the stereotyped nature of lung branching.