[Dynamics od reparative processes in bronchial stump after pneumonectomy in experimental animals]

Repair processes in the bronchus stump after pneumonectomy in 25 rats and 25 guinea-pigs were analysed. The tests were conducted on 1, 3, 7, 14 and 30 days of the postoperative period using bronchus stump and its bottom material for semithin ++ slices and electron microscopy, respectively. At early stages, besides necrotic and necrobiotic changes in the bronchus stump, compensatory and adaptive reactions are also observed. 14 days after operation there was a restoration of epithelial lining and formation of granulation tissue around the stitches. By the 30-th day considerable degenerative and functional changes are detected in the lamina proper, including its cellular elements, as well as in the structure of collagenic, elastic and smooth muscular fibers. Basal cells, endotheliocytes and fibroblasts are the most active sources of regeneration.