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Related Concept Videos

Hypersensitivities01:30

Hypersensitivities

Hypersensitivity, also known as a hypersensitivity reaction or allergic reaction, is a condition where the body's immune system reacts abnormally to a foreign substance. Such substances, that cause hypersensitivity are referred to as an allergen, could be something typically harmless to most people, like pollen or certain foods.
Types of Hypersensitivities
Hypersensitivity reactions are categorized into four types: Type 1, Type 2, Type 3, and Type 4. Each type has a distinct mechanism...
Allergic Reactions: Anaphylaxis01:30

Allergic Reactions: Anaphylaxis

Anaphylaxis is a severe, life-threatening hypersensitivity reaction mediated by Immunoglobulin E (IgE) antibodies. When IgE binds to allergens, it triggers the release of mediators– histamine, leukotrienes, and prostaglandins from mast cells and basophils. These mediators cause vasodilation, edema, and inflammation, leading to various symptoms.The primary allergens causing anaphylaxis include food items (e.g., peanuts, shellfish), drugs (e.g., penicillin, asparaginase, corticotropin, heparin),...
Hypersensitivity Reactions: Delayed Hypersensitivity Reactions01:29

Hypersensitivity Reactions: Delayed Hypersensitivity Reactions

Delayed-Type Hypersensitivity (DTH), or Type IV hypersensitivity, is a cell-mediated immune response. It occurs when T cells, rather than antibodies, mediate a reaction to specific antigens. It is characterized by a delayed onset (1-2 days) and involves the recruitment of macrophages to the inflammation site.The initiation of a DTH response begins with the sensitization of T cells. During this phase, which lasts at least 1-2 weeks, antigen-specific T cells are activated, clonally expanded, and...
Allergic Reactions02:06

Allergic Reactions

Overview
Hypersensitivity Reactions: Immune-Complex Reactions01:19

Hypersensitivity Reactions: Immune-Complex Reactions

Type III hypersensitivity reactions occur when antigen–antibody complexes form and activate the complement system. Normally, these complexes help the clearance of antigens by phagocytes and red blood cells. However, when large numbers of immune complexes are present, they can deposit in tissues—particularly in the walls of blood vessels—leading to inflammation and tissue injury. These deposits trigger complement activation and neutrophil recruitment, resulting in serum sickness, a systemic...
Drug Toxicity: Allergic Reactions01:30

Drug Toxicity: Allergic Reactions

Drug-related allergies are immune-mediated responses triggered by the administration of pharmacological agents. These hypersensitivity reactions are classified based on the immune mechanisms involved. The four primary types—Type I, II, III, and IV—are mediated by different immunological pathways and exhibit distinct clinical manifestations.Type I Hypersensitivity/ IgE-Mediated Reactions: Immunoglobulin E (IgE) immediately mediates Type I hypersensitivity reactions. Upon initial exposure to a...

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Related Experiment Video

Updated: May 24, 2026

Mouse Body Temperature Measurement Using Infrared Thermometer During Passive Systemic Anaphylaxis and Food Allergy Evaluation
04:34

Mouse Body Temperature Measurement Using Infrared Thermometer During Passive Systemic Anaphylaxis and Food Allergy Evaluation

Published on: September 14, 2018

[Food hypersensitivity in children].

Sanja Kolacek1

  • 1Referral Center for Pediatric Gastroenterology and Nutrition, Zagreb University Children's Hospital, Sestre milosrdnice University Hospital Center, Zagreb, Croatia. sanja.kolacek@kdb.hr

Acta Medica Croatica : Casopis Hravatske Akademije Medicinskih Znanosti
|February 25, 2012
PubMed
Summary
This summary is machine-generated.

Food hypersensitivity is a growing public health concern. Accurate diagnosis via challenge tests is crucial for effective management, as avoidance is only recommended for confirmed allergies.

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Mouse Body Temperature Measurement Using Infrared Thermometer During Passive Systemic Anaphylaxis and Food Allergy Evaluation
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Area of Science:

  • Allergy and Immunology
  • Pediatric Nutrition
  • Public Health

Context:

  • Increasing prevalence of food hypersensitivity in children and adults.
  • Self-reported food reactions significantly exceed diagnosed hypersensitivity.
  • Allergic food reactions are more common in children, primarily caused by eight major allergens.

Purpose:

  • To highlight the diagnostic challenges and management strategies for food hypersensitivity.
  • To emphasize the importance of evidence-based diagnostic guidelines.
  • To inform about effective allergy prevention and management in pediatric populations.

Summary:

  • Diagnosis of food allergy requires challenge tests; serology and skin-prick tests have limitations.
  • Strict dietary avoidance is the primary management strategy but only for confirmed allergies.
  • Elimination diets in children can impede growth and maturation; allergen avoidance during pregnancy/lactation/weaning is not recommended for prevention.

Impact:

  • Promotes accurate diagnosis and appropriate management of food hypersensitivity.
  • Reduces risks associated with unnecessary dietary restrictions in children.
  • Provides evidence-based recommendations for public health strategies regarding food allergy.