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Related Experiment Video

Updated: May 24, 2026

Studies on the Anti-Inflammatory Effect of Xiaoyao Pills in The Treatment of Postmenopausal Osteoporosis in Mice

Studies on the Anti-Inflammatory Effect of Xiaoyao Pills in The Treatment of Postmenopausal Osteoporosis in Mice

Published on: August 23, 2024

Early postmenopausal bone loss and what to do about it.

Robert R Recker¹

¹Osteoporosis Research Center, Creighton University, Omaha, Nebraska 68131, USA. rrecker@creighton.edu

Annals of the New York Academy of Sciences

|February 25, 2012

Summary

Women experience peak bone mass in late adolescence, followed by a decline near menopause. Rapid bone loss occurs around the last menstrual period, increasing fracture risk later in life.

Area of Science:

Bone biology and women's health.

Background:

Bone mass accrual continues through adolescence, reaching peak adult levels later.
Menopause onset is associated with changes in bone density.

Purpose of the Study:

To examine lifelong bone mass changes in women.
To clarify the timing of peak bone mass and the onset of bone loss.
To focus on perimenopausal bone loss and fracture risk.

Main Methods:

Review of existing publications on bone mass changes throughout women's lives.
Analysis of data on bone loss timing relative to the last menstrual period.

Main Results:

Peak bone mass is achieved around late adolescence.
Rapid bone loss commences approximately two years before the final menses and concludes four to five years after.

Related Experiment Videos

Last Updated: May 24, 2026

Studies on the Anti-Inflammatory Effect of Xiaoyao Pills in The Treatment of Postmenopausal Osteoporosis in Mice

Studies on the Anti-Inflammatory Effect of Xiaoyao Pills in The Treatment of Postmenopausal Osteoporosis in Mice

Published on: August 23, 2024

Significant, largely irreversible bone loss occurs at the spine, total body, and femoral neck.

Conclusions:

Perimenopausal rapid bone loss is a critical period for bone health.
Understanding this pattern is key for identifying women at risk of osteoporosis and fractures.
Early identification and management strategies are crucial for mitigating later-life fracture risk.