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Induction of pH sensitivity on the fluorescence lifetime of quantum dots by NIR fluorescent dyes
Rui Tang1, Hyeran Lee, Samuel Achilefu
1Department of Radiology, Washington University, St. Louis, Missouri 63110, United States.
Abstract:
Modulation of the fluorescence lifetime (FLT) of CdTeSe/ZnS quantum dots (QDs) by near-IR (NIR) organic chromophores represents a new strategy for generating reproducible pH-sensing nanomaterials. The hybrid construct transfers the pH sensitivity of photolabile NIR cyanine dyes to highly emissive and long-lifetime pH-insensitive QDs, thereby inducing a reproducible FLT change from 29 ns at pH >7 to 12 ns at pH <5. This approach provides an unparalleled large dynamic FLT range for pH sensing at NIR wavelengths.
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