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Biomimetic Materials to Characterize Bacteria-host Interactions
Published on: November 16, 2015
Synthetic polymer nanoparticles conjugated with FimH(A) from E. coli pili to emulate the bacterial mode of epithelial
Lily Yun Lin1, Kristin M Tiemann, Yali Li
1Department of Chemistry and Chemical Engineering, Texas A&M University, P.O. Box 30012, College Station, Texas 77842, USA.
Journal of the American Chemical Society
|February 25, 2012
Abstract:
Amphiphilic block copolymer nanoparticles are conjugated with uropathogenic Escherichia coli type 1 pilus adhesin FimH(A) through amidation chemistry to enable bladder epithelial cell binding and internalization of the nanoparticles in vitro.
