Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Disorders of the Male Reproductive System

Disorders of the Male Reproductive System

Men's health issues are increasingly recognized as significant, with several conditions posing common threats. Among these, testicular cancer is especially prevalent in younger men, particularly those aged 20 to 35 years. The disease often manifests as a painless mass in the testicles, sometimes accompanied by a sensation of heaviness or a dull ache.
Prostate disorders are another major concern. These conditions can impair urinary flow due to the prostate's location around the urethra. Symptoms...

Abnormal Proliferation

Abnormal Proliferation

Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the daughter...

Abnormal Proliferation

Abnormal Proliferation

Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the daughter...

Tumor Progression

Tumor Progression

Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...

Cellular Adaptation III: Hyperplasia

Cellular Adaptation III: Hyperplasia

Hyperplasia is an increase in the number of cells in a tissue or organ due to enhanced cell division. It is an adaptive, controlled response to stimuli such as injury, hormones, or stress, involving mitosis to produce genetically identical cells and support tissue repair and regeneration.Tissue CapacityCertain tissues, including the epidermis, intestinal epithelium, bone marrow, and fibroblasts, have a high potential for hyperplasia. Others, such as bone, cartilage, and smooth muscle, show...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

AES-CTR-based modulation-layer encryption compatible with high-speed coherent optical transport.

Optics letters·2026

Same author

A Case of Cold Agglutinin Disease With Transformation to High-Grade Lymphoma During Sutimlimab Treatment.

Cureus·2025

Same author

Association of renal volumetry and histological features with marginal donors: risks for donors and recipients in living donor kidney transplantation.

Clinical and experimental nephrology·2024

Same author

Combined endovascular therapy and surgery for central giant cell granuloma in the temporal bone: A case report.

Surgical neurology international·2024

Same author

Loss of p16 Immunoexpression and Deletions of CDKN2A in the Progression of Extramammary Paget Disease: An Immunohistochemical and Genetic Study of 24 Invasive/Metastatic Cases.

The American Journal of dermatopathology·2024

Same author

Overexpression of MicroRNA-138 Affects the Proliferation and Invasion of Urothelial Carcinoma Cells by Suppressing SOX9 Expression.

Biomedicines·2023

Search research articles

Related Experiment Video

Updated: May 24, 2026

Isolation, Culture, and Characterization of Prostate Cancer-Associated Fibroblasts

Isolation, Culture, and Characterization of Prostate Cancer-Associated Fibroblasts

Published on: August 1, 2025

Phyllodes tumor of the prostate.

Tomomi Fujii¹, Keiji Shimada, Nobumichi Tanaka

¹Department of Pathology Urology, Nara Medical University School of Medicine, Kashihara, Nara, Japan.

Pathology International

|February 25, 2012

Summary

This case report details a rare phyllodes tumor of the prostate in a 47-year-old man. The tumor presented with high prostate-specific antigen (PSA) levels, which normalized after surgical removal.

More Related Videos

Focal Laser Ablation of Prostate Cancer: An Office Procedure

Focal Laser Ablation of Prostate Cancer: An Office Procedure

Published on: March 30, 2021

A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer

A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer

Published on: March 6, 2018

Related Experiment Videos

Last Updated: May 24, 2026

Isolation, Culture, and Characterization of Prostate Cancer-Associated Fibroblasts

Isolation, Culture, and Characterization of Prostate Cancer-Associated Fibroblasts

Published on: August 1, 2025

Focal Laser Ablation of Prostate Cancer: An Office Procedure

Focal Laser Ablation of Prostate Cancer: An Office Procedure

Published on: March 30, 2021

A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer

A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer

Published on: March 6, 2018

Area of Science:

Urology
Oncology
Pathology

Background:

Phyllodes tumors are rare neoplasms typically found in the breast.
Prostate cancer is a common malignancy in men, often detected via prostate-specific antigen (PSA) screening.

Observation:

A 47-year-old male presented with hematospermia and significantly elevated serum PSA (60.76 ng/mL).
Needle biopsy showed atypical stromal cells; radical prostatectomy revealed a 2.9 cm phyllodes tumor.
Immunohistochemistry identified atypical stromal cells positive for vimentin, AR, ER, progesterone, and 5α-reductase.

Findings:

Genomic analysis detected a gain of 11p13 (WT1 gene) and losses of 1p36.23 and 12p12.1.
The elevated PSA levels were attributed to hyperplastic luminal cells potentially driven by 5α-reductase-positive stromal and epithelial cells.
Post-surgery, PSA levels normalized, with no recurrence or metastasis after 2 years.

Implications:

This case expands the known pathology of prostate tumors.
Understanding the hormonal and genetic drivers of such rare tumors is crucial for diagnosis and management.
Highlights the importance of comprehensive histopathological and molecular analysis in complex cases.