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Related Concept Videos

Type I Diabetes II: Pathophysiology01:26

Type I Diabetes II: Pathophysiology

Type 1 diabetes mellitus arises from an immune-mediated destruction of pancreatic β-cells, resulting in an absolute deficiency of insulin. This process develops in genetically susceptible individuals when autoimmunity, environmental exposures, and immunologic dysregulation converge to trigger a targeted attack on the insulin-producing cells of the pancreas. The β-cells are located within the islets of Langerhans and are essential for regulating blood glucose by facilitating cellular uptake of...
Diabetes Mellitus: Type 2 and Gestational01:22

Diabetes Mellitus: Type 2 and Gestational

Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
Type II Diabetes II: Pathophysiology01:24

Type II Diabetes II: Pathophysiology

PathophysiologyType 2 diabetes mellitus (T2DM ) is a chronic metabolic disorder characterized by insulin resistance and progressive pancreatic β-cell dysfunction, leading to impaired glucose homeostasis. It results from interactions among genetic predisposition, environmental factors, and metabolic stressors, such as overnutrition and a sedentary lifestyle.Insulin Resistance and Glucose DysregulationEarly T2DM involves insulin resistance in skeletal muscle, adipose tissue, and the liver.
Diabetes Mellitus: Overview and Type I Subtype01:22

Diabetes Mellitus: Overview and Type I Subtype

Diabetes mellitus is a chronic metabolic disorder characterized by high blood glucose levels due to inadequate insulin production, insulin resistance, or both. The condition affects millions worldwide and can significantly impact their health and quality of life.
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Related Experiment Video

Updated: May 24, 2026

Homogeneous Time-resolved Förster Resonance Energy Transfer-based Assay for Detection of Insulin Secretion
07:30

Homogeneous Time-resolved Förster Resonance Energy Transfer-based Assay for Detection of Insulin Secretion

Published on: May 10, 2018

[Corticosteroids and diabetes mellitus].

Laura Gagliardi1, Claire Le Jeunne

  • 1Université Paris-Descartes, AP-HP, Hôtel-Dieu, service de médecine interne, 75004 Paris, France.

Presse Medicale (Paris, France : 1983)
|February 25, 2012
PubMed
Summary

Corticosteroid medications can disrupt or reveal diabetes mellitus. Monitoring blood sugar is crucial during long-term corticosteroid treatment for prevention and management.

Area of Science:

  • Endocrinology
  • Metabolic Diseases

Context:

  • Corticosteroid therapy is widely used but can significantly impact glucose metabolism.
  • The mechanisms underlying corticosteroid-induced diabetes (CID) are not fully elucidated.
  • Epidemiological data on CID predisposing factors and incidence remain limited.

Purpose:

  • To highlight the potential for corticosteroids to deregulate or unmask diabetes mellitus.
  • To discuss potential mechanisms involving beta-cell function and tissue sensitivity.
  • To emphasize the need for increased awareness and monitoring of glucose levels in patients on corticosteroids.

Summary:

  • Corticosteroids can cause or reveal diabetes mellitus through effects on pancreatic beta-cells and insulin sensitivity.
  • Predisposing factors and the exact frequency of corticosteroid-induced diabetes are not well-established.

Related Experiment Videos

Last Updated: May 24, 2026

Homogeneous Time-resolved Förster Resonance Energy Transfer-based Assay for Detection of Insulin Secretion
07:30

Homogeneous Time-resolved Förster Resonance Energy Transfer-based Assay for Detection of Insulin Secretion

Published on: May 10, 2018

  • Management strategies for CID are similar to Type II diabetes, necessitating regular glycemic monitoring.
  • Impact:

    • Increased clinical vigilance for diabetes in patients prescribed corticosteroids.
    • Potential for earlier detection and intervention, improving patient outcomes.
    • Highlights the importance of understanding drug-induced metabolic disturbances.