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In human women, oogenesis produces one mature egg cell or ovum for every precursor cell that enters meiosis. This process differs in two unique ways from the equivalent procedure of spermatogenesis in males. First, meiotic divisions during oogenesis are asymmetric, meaning that a large oocyte (containing most of the cytoplasm) and minor polar body are produced as a result of meiosis I, and again following meiosis II. Since only oocytes will go on to form embryos if fertilized, this unequal...

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Related Experiment Video

Updated: May 24, 2026

Establishment of an Experimental Mouse Model of Endometrioma to Study its Related Infertility

Establishment of an Experimental Mouse Model of Endometrioma to Study its Related Infertility

Published on: April 5, 2024

Association between endometriosis and risk of histological subtypes of ovarian cancer: a pooled analysis of

Celeste Leigh Pearce¹, Claire Templeman, Mary Anne Rossing

¹Department of Preventive Medicine, University of Southern California, Los Angeles, CA, USA. cpearce@usc.edu

The Lancet. Oncology

|February 25, 2012

Summary

Endometriosis increases the risk of clear-cell, low-grade serous, and endometrioid ovarian cancers. This study found no association between endometriosis and mucinous or high-grade serous invasive ovarian cancers or borderline tumors.

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Area of Science:

Gynecologic Oncology
Reproductive Epidemiology
Cancer Risk Factors

Background:

Endometriosis is a known risk factor for epithelial ovarian cancer.
The association between endometriosis and specific ovarian cancer subtypes, including borderline tumors, requires further clarification.

Purpose of the Study:

To investigate the association between a history of endometriosis and the risk of developing specific histological subtypes of invasive ovarian cancer and borderline ovarian tumors.

Main Methods:

A pooled analysis of 13 international case-control studies from the Ovarian Cancer Association Consortium.
Logistic regression models were used to assess the association between self-reported endometriosis and ovarian cancer risk, adjusting for relevant covariates.

Main Results:

Endometriosis was significantly associated with an increased risk of clear-cell (OR 3.05), low-grade serous (OR 2.11), and endometrioid (OR 2.04) invasive ovarian cancers.
No significant association was found between endometriosis and mucinous or high-grade serous invasive ovarian cancers, or serous or mucinous borderline ovarian tumors.

Conclusions:

Women with endometriosis have an elevated risk for specific ovarian cancer subtypes, particularly clear-cell, low-grade serous, and endometrioid types.
Further research into the mechanisms of malignant transformation of endometriosis is crucial for identifying high-risk individuals.