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Related Experiment Video

Updated: May 24, 2026

Automated Contraction Analysis of Human Engineered Heart Tissue for Cardiac Drug Safety Screening

Automated Contraction Analysis of Human Engineered Heart Tissue for Cardiac Drug Safety Screening

Published on: April 15, 2017

Computational analysis of contractility in engineered heart tissue.

Grant Mathews¹, Claus Sondergaard, Angela Jeffreys

¹University of California Davis School of Medicine, Department of Surgery, Division of Cardiothoracic Surgery, Sacramento, CA 95817, USA. grant.m.mathews@gmail.com

IEEE Transactions on Bio-Medical Engineering

|February 25, 2012

Summary

A new computer algorithm objectively analyzes engineered heart tissue (EHT) contractile function. This tool efficiently processes EHT force data, improving accuracy and speed for cardiovascular research.

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Analysis of Cardiac Contractile Dysfunction and Ca2+ Transients in Rodent Myocytes

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Published on: May 25, 2022

Area of Science:

Biomedical Engineering
Cardiovascular Research
Tissue Engineering

Background:

Engineered heart tissue (EHT) shows promise for heart failure therapy and drug testing.
Assessing EHT contractile function is crucial but manual analysis is time-consuming and subjective.
Automated analysis is needed for efficient and objective evaluation of EHT performance.

Purpose of the Study:

To develop a computer algorithm for objective and efficient analysis of EHT force data.
To overcome limitations of manual data analysis in contractile function assessment.

Main Methods:

Developed a computer algorithm incorporating data filtering and contraction detection/validation.
Algorithm performs inter/intracontractile and intersample analyses.
Evaluated algorithm accuracy and efficiency against human operators.

Main Results:

The algorithm demonstrated high accuracy in detecting, validating, and measuring EHT contractions.
It efficiently processed large datasets, enabling analysis of force-length and force-frequency relationships.
The tool facilitated comparison of contractile parameters like peak systolic force generation.

Conclusions:

The developed computer algorithm provides an objective and efficient method for assessing EHT contractile function.
This tool is a valuable adjunct for research in cardiovascular treatments and tissue engineering.