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Updated: May 24, 2026

Isolation of Mouse Interstitial Valve Cells to Study the Calcification of the Aortic Valve In Vitro
Published on: May 10, 2021
Pathophysiologic mechanisms of calcific aortic stenosis
Alexandros Alexopoulos1, Andreas Kaoukis, Helen Papadaki
1Department of Cardiology, Athens General Hospital, Mesogeion Avenue, 154, 15669 Athens, Greece. aalexop@upatras.gr
Abstract:
Calcific aortic stenosis (CAS) comprises the leading indication for valve replacement in the Western world. Until recently, progressive calcification was considered to be a passive process. Emerging evidence, however, suggests that degenerative aortic stenosis constitutes an active process involving stimulation of several pathophysiologic pathways such as inflammation and osteogenesis. In addition, CAS and atherosclerosis share common features regarding histopathology of lesions. These novel data raise a new perspective on the prevention and treatment of disease. The current article reviews the most important pathophysiologic mechanisms of senile aortic stenosis.
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