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Mitochondrial evolution in HIV-infected children receiving first- or second-generation nucleoside analogues

Constanza Morén1, Antoni Noguera-Julian, Glòria Garrabou

  • 1Mitochondrial Research Laboratory, Internal Medicine Department, Hospital Clinic of Barcelona, Institut d'Investigacions Biomèdiques August Pi i Sunyer, University of Barcelona, Barcelona, Spain. cmoren1@clinic.ub.es

Journal of Acquired Immune Deficiency Syndromes (1999)
|February 25, 2012
PubMed
Summary

First-generation nucleoside reverse transcriptase inhibitors (1gNRTIs) used in highly active antiretroviral therapy (HAART) cause greater mitochondrial damage in children than second-generation NRTIs (2gNRTIs). This is evidenced by higher lactate levels and reduced cytochrome c oxidase activity, supporting the use of 2gNRTIs.

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