Structures of compounds with antigonadotropic activity obtained by in vitro oxidation of caffeic acid

¹Institut für Pharmazeutische Biologie und Phytochemie der Westfälischen Wilhelms-Universität, Münster, Federal Republic of Germany.

|August 1, 1990

Abstract:

Two new cyclolignan derivatives were isolated by HPLC from the mixture of substances obtained after oxidation of caffeic acid with KMnO4. Their structures were elucidated by spectroscopic methods as 2,3-dicarboxy-6,7-dihydroxy-1-(3', 4'-dihydroxy)-phenyl-1, 2-dihydronaphthalene (1) and 3-carboxy-6,7-dihydroxy-1-(3', 4'-dihydroxy)-phenylnaphthalene (2). Compounds 1 and 2 exhibit antigonadotropic activity as do the extracts of crude drugs of Lycopus europaeus and Lithospermum officinale after oxidation by plant enzymes.

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Abstract:

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