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Published on: April 1, 2019
Are myocardial infarction--associated single-nucleotide polymorphisms associated with ischemic stroke?
Yu-Ching Cheng1, Christopher D Anderson, Silvia Bione
1Department of Medicine, University of Maryland School of Medicine, 660 W Redwood St, Howard Hall, Room 492, Baltimore, MD 21201, USA.
Stroke
|February 25, 2012
Summary
Genetic variants linked to heart attacks (myocardial infarction) and coronary artery disease do not appear to significantly increase ischemic stroke risk. Further research may explore associations with specific stroke subtypes.
Area of Science:
- Genetics
- Cardiovascular Disease
- Neurology
Background:
- Ischemic stroke (IS) and coronary artery disease (CAD) share common risk factors.
- Genetic predisposition may play a role in both conditions.
Purpose of the Study:
- To investigate if single-nucleotide polymorphisms (SNPs) associated with myocardial infarction (MI) or CAD are also associated with IS.
- To test the hypothesis of shared genetic etiology between MI/CAD and IS.
Main Methods:
- Meta-analysis of 11 MI/CAD-associated SNPs across 9 studies (6865 cases, 11395 controls).
- SNPs were genotyped or imputed; logistic regression and inverse variance weighted random-effect models were used.
Main Results:
- None of the evaluated SNPs showed a significant association with overall IS or major stroke subtypes after adjusting for multiple comparisons.
- The study possessed sufficient power to detect moderate odds ratios (e.g., 1.09 for IS, 1.20 for subtypes).
Conclusions:
- Major genetic loci for MI risk do not appear to confer a similar magnitude of risk for overall IS.
- Disparate underlying biological mechanisms may differentiate acute ischemic coronary and cerebrovascular events.
- The possibility of moderate associations with specific IS subtypes cannot be excluded.
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