Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Multipotency of Hematopoietic Stem Cells

Multipotency of Hematopoietic Stem Cells

The hematopoietic stem cells or HSCs are multipotent, meaning they can differentiate and give rise to all blood and immune cells. HSCs are maintained in the quiescent stage until an external stimulus initiates their differentiation. The multipotent HSCs exist as two heterogeneous populations, long-term repopulating cells (LTRC) and short-term repopulating cells (STRC). The two HSC populations have different surface markers or receptors and are classified based on quiescence and long-term...

Regulation of Angiogenesis and Blood Supply

Regulation of Angiogenesis and Blood Supply

Rapidly dividing tumors, embryos, and wounded tissues require more oxygen than usual, lowering the oxygen concentration in the blood. At low oxygen or hypoxic conditions, an oxygen-sensitive transcription factor called the hypoxia-inducible factor 1 or HIF1 is activated. HIF1 is a dimeric protein of alpha (ɑ) and beta (β) subunits. Under optimal oxygen conditions, HIF1β is present in the nucleus while HIF1ɑ remains in the cytosol. HIF1ɑ is hydroxylated by prolyl hydroxylase and factor...

Mechanism of Angiogenesis

Mechanism of Angiogenesis

Blood vessel formation starts early during embryonic development, around day 7. In the extraembryonic yolk sac, mesodermal precursor cells called hemangioblast proliferate and differentiate into angioblast. Angioblasts express vascular endothelial growth factor receptor 2 or VEGFR2, which binds VEGF-A, a proangiogenic factor, guiding blood vessel formation. VEGF signaling promotes angioblasts to form a blood island in the developing embryo. Angioblasts further differentiate, giving rise to...

Production of Formed Elements

Production of Formed Elements

Hemangioblasts are multipotent stem cells originating from the mesoderm. They give rise to hematopoietic stem cells (HSCs), which undergo hematopoiesis to produce all the formed elements of blood. This process is regulated by a complex network of hematopoietic growth factors, including transcription factors, growth factors, and cytokines. These factors stimulate the HSCs to divide and differentiate, though some HSCs remain undifferentiated to maintain a self-renewing pool.
Most HSCs commit to...

Hematopoiesis

Hematopoiesis

The process of blood cell formation is called hematopoiesis. Hematopoiesis starts early during development, on the seventh day of embryogenesis. This phase of hematopoiesis is called the primitive wave, wherein the extraembryonic yolk sac allows the production of erythroid cells and endothelial cells from a common precursor called hemangioblast. The erythroid cells provide oxygen to support the growth of the rapidly dividing embryo. Hemangioblasts later develop into hematopoietic stem cells or...

The Effect of Aging on Tissues

The Effect of Aging on Tissues

Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

A Review of the Management of Obesity in Primary Care.

Clinical obesity·2025

Same author

Place-based household vouchers for locally supplied fruit and vegetables: the Fresh Street pilot cluster randomised controlled trial.

BMC public health·2025

Same author

Systemic biomarkers currently implicated in the formation of abdominal wall hernia: A systematic review of the literature.

American journal of surgery·2020

Same author

Expectations of therapeutic radiography students in Wales about transitioning to practice during the Covid-19 pandemic as registrants on the HCPC temporary register.

Radiography (London, England : 1995)·2020

Same author

The radiology impact of healthcare errors during shift work.

Radiography (London, England : 1995)·2020

Same author

Suppression of SIRT1 in Diabetic Conditions Induces Osteogenic Differentiation of Human Vascular Smooth Muscle Cells via RUNX2 Signalling.

Scientific reports·2019

Search research articles

Related Experiment Video

Updated: May 24, 2026

Isolation of Endothelial Progenitor Cells from Healthy Volunteers and Their Migratory Potential Influenced by Serum Samples After Cardiac Surgery

Isolation of Endothelial Progenitor Cells from Healthy Volunteers and Their Migratory Potential Influenced by Serum Samples After Cardiac Surgery

Published on: February 14, 2017

Endothelial progenitor cells enter the aging arena.

K Williamson¹, S E Stringer, M Y Alexander

¹Cardiovascular Research Group, School of Biomedicine, University of Manchester Manchester, UK.

Frontiers in Physiology

|February 25, 2012

Summary

Aging impairs endothelial progenitor cells (EPCs), crucial for vascular repair, increasing disease risk. This review explores age-related EPC decline and potential therapies to restore vascular health.

Keywords:

age endothelial progenitor cells estrogen nitric oxide oxidative stress senescence vasculature

More Related Videos

Isolation of Endothelial Progenitor Cells from Human Umbilical Cord Blood

Isolation of Endothelial Progenitor Cells from Human Umbilical Cord Blood

Published on: September 14, 2017

Murine Dermal Lymphatic Endothelial Cell Isolation

Murine Dermal Lymphatic Endothelial Cell Isolation

Published on: July 21, 2023

Related Experiment Videos

Last Updated: May 24, 2026

Isolation of Endothelial Progenitor Cells from Healthy Volunteers and Their Migratory Potential Influenced by Serum Samples After Cardiac Surgery

Isolation of Endothelial Progenitor Cells from Healthy Volunteers and Their Migratory Potential Influenced by Serum Samples After Cardiac Surgery

Published on: February 14, 2017

Isolation of Endothelial Progenitor Cells from Human Umbilical Cord Blood

Isolation of Endothelial Progenitor Cells from Human Umbilical Cord Blood

Published on: September 14, 2017

Murine Dermal Lymphatic Endothelial Cell Isolation

Murine Dermal Lymphatic Endothelial Cell Isolation

Published on: July 21, 2023

Area of Science:

Gerontology
Cardiovascular Research
Regenerative Medicine

Background:

Age is a primary risk factor for vascular diseases like atherosclerosis.
Current treatments improve cardiovascular disease prognosis but mortality remains high in older adults.
There is a growing need for alternative therapeutic strategies due to increased life expectancy.

Purpose of the Study:

To review the current understanding of endothelial progenitor cells (EPCs).
To examine the impact of aging on EPC function and vascular repair.
To identify potential therapeutic targets for age-related vascular dysfunction.

Main Methods:

Literature review on aging, EPCs, and vascular repair.
Analysis of age-associated changes in EPC number and function.
Identification of therapeutic strategies targeting EPCs.

Main Results:

Aging significantly reduces the number and impairs the function of EPCs.
Diminished EPC capacity compromises endothelial regeneration and maintenance.
Age-related decline in EPCs contributes to increased vascular disease risk.

Conclusions:

EPCs are vital for vascular health, but their function declines with age.
Targeting EPCs offers a promising avenue for treating age-related vascular diseases.
Further research into EPC-mediated repair can lead to novel therapeutic interventions.