Related Experiment Video
Updated: May 24, 2026

Study of In Vivo Glucose Metabolism in High-fat Diet-fed Mice Using Oral Glucose Tolerance Test (OGTT) and Insulin Tolerance Test (ITT)
Published on: January 7, 2018
Glycemic Profiles of Healthy Individuals with Low Fasting Plasma Glucose and HbA1c
Kyoko Nomura1, Tomoyuki Saitoh, Gwang U Kim
1Department of Hygiene and Public Health, School of Medicine, Teikyo University, Kaga 2-11-1, Itabashi, Tokyo 173-8605, Japan.
Abstract:
Scant data exists on glucose profile variability in healthy individuals. Twenty-nine healthy subjects without diabetes (86% male; mean age, 38 years) were measured by a CGM system and under real-life conditions. The median percentage of time spent on the blood glucose >7.8 mmol/L for 24 hrs was greater than 10% in both NFG and IFG groups. When subjects were divided into either NFG group (i.e., FPG levels of <5.6 mmol/L; n = 22) or IFG group (FPG levels of 5.6-6.9 mmol/L; n = 7), all CGM indicators investigated but GRADE scores, including glucose variability measures, monitoring excursions, hyperglycemia, hypoglycemia, and 24-hour AUC, did not differ significantly between the two groups. GRADE score and its euglycemia% were significantly different between the two groups. Among various CGM indicators, GRADE score may be a sensitive indicator to discriminate glucose profiles between subjects with NFG and those with IFG.
More Related Videos
Related Concept Videos
Hyperglycemia
Hypoglycemia and Glucagon
Hypoglycemia
Type II Diabetes Mellitus III: Clinical Manifestations and Diagnosis
Glucose Homeostasis: Regulation of Blood Glucose
During fasting, when blood glucose levels are low, the pancreas secretes glucagon. it...
Diabetes: Symptoms, Diagnosis, and Complications

