Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Acute Pancreatitis I: Introduction01:25

Acute Pancreatitis I: Introduction

Acute pancreatitis is the sudden inflammation of the pancreas caused by the early activation of digestive enzymes, leading to the autodigestion of pancreatic tissue. This results in local inflammation and, in severe cases, systemic complications.EtiologyUnderstanding the underlying causes is crucial, as identifying the etiology guides treatment and anticipates complications. Acute pancreatitis can be triggered by various factors, typically grouped into the following clinical categories.Biliary...
Acute Pancreatitis I: Introduction01:27

Acute Pancreatitis I: Introduction

Pancreatitis is inflammation of the pancreas, an organ located behind the stomach. It can be either acute or chronic.
Acute pancreatitis is characterized by rapid inflammation of the pancreas, often caused by factors like gallstone blockage or excessive alcohol consumption. Chronic pancreatitis, on the other hand, is a slow, progressive inflammation that may result from long-term alcohol abuse, obstructions in the pancreatic duct, or genetic factors.
The causes of acute pancreatitis include:
Chronic Pancreatitis I: Introduction01:25

Chronic Pancreatitis I: Introduction

Chronic pancreatitis is a long-standing, relapsing inflammation of the pancreas, characterized by irreversible damage to the gland. It results in progressive destruction of the pancreatic parenchyma, fibrosis, and eventual loss of both exocrine and endocrine function. The disease may evolve gradually after multiple episodes of acute pancreatitis or develop independently.EtiologyChronic pancreatitis can arise from a variety of causes:Alcohol use is the leading cause, accounting for 70–80% of...
Chronic Pancreatitis I: Introduction01:24

Chronic Pancreatitis I: Introduction

The pancreas, an elongated and flat gland situated behind the stomach, serves a vital function in digesting food and managing blood sugar levels.
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
Chronic Pancreatitis II: Pathophysiology01:21

Chronic Pancreatitis II: Pathophysiology

Chronic pancreatitis is a progressive and irreversible inflammation of the pancreas, most often caused by long-term alcohol abuse, but it can also be related to ductal obstruction, smoking, or genetic factors.Chronic pancreatitis occurs when the pancreas is repeatedly exposed to harmful agents like alcohol, smoking, ductal obstruction, or genetic predisposition. These factors lead to the release of toxic metabolites and inflammatory cytokines, sustaining chronic inflammation in the pancreatic...
Acute Pancreatitis II: Pathophysiology01:21

Acute Pancreatitis II: Pathophysiology

The pathophysiology of acute pancreatitis centers on injury to pancreatic acinar cells, which initiates a cascade of harmful intracellular events.This injury leads to premature activation of trypsinogen to trypsin in the pancreas. Trypsin then activates other digestive enzymes, such as chymotrypsin, elastase, and phospholipase A2, which begin breaking down pancreatic tissue. The resulting autodigestion causes local inflammation, tissue swelling, hemorrhage, and fat necrosis.Injured acinar cells...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[Use of itopride in the symptoms of functional dyspepsia in Russia: results of a phase IV prospective open-label multicenter clinical trial].

Terapevticheskii arkhiv·2014
Same author

[Gastroesophageal reflux disease model].

Eksperimental'naia i klinicheskaia gastroenterologiia = Experimental & clinical gastroenterology·2014
Same author

[Biliary pancreatitis].

Eksperimental'naia i klinicheskaia gastroenterologiia = Experimental & clinical gastroenterology·2012
Same author

[Study of the esophagus and stomach acidification (according to the interpretation of 24-hour pH monitoring data)].

Eksperimental'naia i klinicheskaia gastroenterologiia = Experimental & clinical gastroenterology·2011
Same author

[Calculous pancreatitis].

Eksperimental'naia i klinicheskaia gastroenterologiia = Experimental & clinical gastroenterology·2011
Same author

[Pharmacoeconomic analysis of treatment of certain diseases of the digestive system].

Eksperimental'naia i klinicheskaia gastroenterologiia = Experimental & clinical gastroenterology·2011

Related Experiment Video

Updated: May 24, 2026

Sodium Taurocholate Induced Severe Acute Pancreatitis in C57BL/6 Mice
06:35

Sodium Taurocholate Induced Severe Acute Pancreatitis in C57BL/6 Mice

Published on: June 28, 2021

[Idiopathic pancreatitis].

Iu V Vasil'ev

    Eksperimental'Naia I Klinicheskaia Gastroenterologiia = Experimental & Clinical Gastroenterology
    |February 28, 2012
    PubMed
    Summary
    This summary is machine-generated.

    Idiopathic pancreatitis is a complex condition. This review covers its causes, diagnosis, and current treatment options for better patient management.

    More Related Videos

    A Simple and Rapid Method for Simultaneous Isolation of Primary Islets and Primary Pancreatic Acinar Cells from Mice
    14:39

    A Simple and Rapid Method for Simultaneous Isolation of Primary Islets and Primary Pancreatic Acinar Cells from Mice

    Published on: January 9, 2026

    Establishment of a Mouse Severe Acute Pancreatitis Model using Retrograde Injection of Sodium Taurocholate into the Biliopancreatic Duct
    07:10

    Establishment of a Mouse Severe Acute Pancreatitis Model using Retrograde Injection of Sodium Taurocholate into the Biliopancreatic Duct

    Published on: April 1, 2022

    Related Experiment Videos

    Last Updated: May 24, 2026

    Sodium Taurocholate Induced Severe Acute Pancreatitis in C57BL/6 Mice
    06:35

    Sodium Taurocholate Induced Severe Acute Pancreatitis in C57BL/6 Mice

    Published on: June 28, 2021

    A Simple and Rapid Method for Simultaneous Isolation of Primary Islets and Primary Pancreatic Acinar Cells from Mice
    14:39

    A Simple and Rapid Method for Simultaneous Isolation of Primary Islets and Primary Pancreatic Acinar Cells from Mice

    Published on: January 9, 2026

    Establishment of a Mouse Severe Acute Pancreatitis Model using Retrograde Injection of Sodium Taurocholate into the Biliopancreatic Duct
    07:10

    Establishment of a Mouse Severe Acute Pancreatitis Model using Retrograde Injection of Sodium Taurocholate into the Biliopancreatic Duct

    Published on: April 1, 2022

    Area of Science:

    • Gastroenterology
    • Internal Medicine

    Context:

    • Idiopathic pancreatitis presents diagnostic and therapeutic challenges.
    • Understanding its underlying mechanisms is crucial for effective patient care.

    Purpose:

    • To provide a comprehensive overview of the current knowledge on idiopathic pancreatitis.
    • To detail the etiopathogenesis, diagnostic methods, and treatment strategies.

    Summary:

    • Etiopathogenesis: Discusses the unknown causes and contributing factors.
    • Diagnosis: Outlines key diagnostic criteria and imaging techniques.
    • Treatment: Reviews current therapeutic approaches and management guidelines.

    Impact:

    • Aims to enhance clinical decision-making for idiopathic pancreatitis.
    • Contributes to the body of knowledge for researchers and clinicians.
    • Facilitates improved patient outcomes through evidence-based information.