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Related Experiment Videos

Plasma testosterone is associated with Framingham risk score.

Brandon Chock1, Tzu-Chun Lin, Chin-Shang Li

  • 1Veterans Affairs Northern California Health Care System (VANCHCS), Martinez, CA, USA. Brandon.X.Chock@kp.org

The Aging Male : the Official Journal of the International Society for the Study of the Aging Male
|February 28, 2012
PubMed
Summary

Lower testosterone levels may indicate increased cardiovascular disease risk. This study found a negative association between testosterone and the Framingham risk score in male veterans.

Related Experiment Videos

Area of Science:

  • Endocrinology
  • Cardiovascular Medicine
  • Public Health

Background:

  • The Framingham risk score estimates 10-year cardiovascular disease (CVD) risk.
  • Testosterone levels can influence and be influenced by CVD risk factors.

Purpose of the Study:

  • To investigate the association between testosterone levels and cardiovascular risk using the Framingham risk score.
  • To analyze data from a Veterans Affairs (VA) database.

Main Methods:

  • Retrospective chart review of male veterans aged 20 years or older.
  • Exclusion of patients with pre-existing cardiovascular disease, stroke, or diabetes.
  • Data collection on total plasma testosterone levels from 2008.

Main Results:

  • 1,479 male veterans (mean age 61) were included.
  • Framingham risk score showed a negative association with total and free testosterone.
  • Testosterone levels correlated with lipid profiles, BMI, and blood pressure medication use.

Conclusions:

  • Lower plasma testosterone may be an indicator of cardiovascular risk factors.
  • Reduced testosterone could suggest an increased risk for heart disease.