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Related Concept Videos

Non-LTR Retrotransposons03:18

Non-LTR Retrotransposons

As the name suggests, non-LTR retrotransposons lack the long terminal repeats characteristic of the LTR retrotransposons. Additionally, both LTR and non-LTR retrotransposons use distinct mechanisms of mobilization. Non-LTR retrotransposons are further divided into two classes - Long interspersed nuclear elements (LINEs) and short interspersed nuclear elements (SINEs), both of which occur abundantly in most mammals, including humans. Some of the active non-LTR retrotransposons in humans are L1...
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Pulmonary Hypertension: Classification and Pathogenesis

Pulmonary hypertension (PH) is a severe health condition in which the mean pulmonary arterial pressure increases to 25 mmHg or more, even when the body is at rest. This high pressure in the blood vessels that transport blood from the heart to the lungs can cause various symptoms, including shortness of breath, can lead to right heart failure, and significantly affect the overall quality of life.
There are various classifications for PH, each relating to different underlying causes and also...
Exon Recombination02:32

Exon Recombination

The evolution of new genes is critical for speciation. Exon recombination, also known as exon shuffling or domain shuffling, is an important means of new gene formation. It is observed across vertebrates, invertebrates, and in some plants such as potatoes and sunflowers. During exon recombination, exons from the same or different genes recombine and produce new exon-intron combinations, which might evolve into new genes. 
Exon shuffling follows “splice frame rules.” Each exon has three reading...

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Related Experiment Video

Updated: May 24, 2026

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
04:44

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease

Published on: June 16, 2020

Genetic interstitial lung disease.

Megan Stuebner Devine1, Christine Kim Garcia

  • 1Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Eugene McDermott Center for Human Growth and Development, University of Texas Southwestern Medical Center, Dallas, TX 75390-8591, USA.

Clinics in Chest Medicine
|February 28, 2012
PubMed
Summary
This summary is machine-generated.

Interstitial lung diseases (ILDs) are over 100 lung disorders affecting lung tissues. This review focuses on inherited ILDs in adults and the role of genetic testing.

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Area of Science:

  • Pulmonology
  • Genetics
  • Internal Medicine

Background:

  • Interstitial lung diseases (ILDs), also known as diffuse parenchymal lung diseases, encompass over 100 distinct pulmonary disorders.
  • These conditions affect the lung tissue and spaces surrounding the alveoli, leading to significant respiratory impairment.

Observation:

  • Patients with ILDs commonly exhibit symptoms such as shortness of breath and cough.
  • Clinical findings often include pulmonary restriction, reduced diffusion capacity, and characteristic radiographic patterns like alveolar or reticulonodular infiltrates.

Findings:

  • This review specifically examines inherited forms of ILDs.
  • The focus is on conditions relevant to adult patients managed by pulmonologists.

Implications:

  • Genetic testing may offer valuable insights for diagnosing and managing inherited ILDs.
  • Understanding the genetic basis of ILDs can guide personalized treatment strategies and patient counseling.