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The relationship between polymorphisms of interleukin-4 gene and silicosis

Guo Feng Fang¹, Xue Yun Fan, Fu Hai Shen

¹Department of Occupational and Environmental Health, School of Public Health, Hebei United University, Tangshan 063000, Hebei, China.

Biomedical and Environmental Sciences : BES

|February 28, 2012

Abstract

Objective:

To explore the relationship between polymorphisms of interleukin-4 (IL-4) gene (-33, +45, intron3, +429, +448) and the susceptibility of silicosis.

Methods:

A case-control study was carried out. 101 silicosis patients were selected as cases. As strictly matching, 121 of non silicosis workers were selected as the controls. The polymophisms of IL-4 (five locus) were detected by the method of polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) techniques.

Results:

The GA genotype in the IL-4+429 locus and the CC genotype in the IL-4+448 locus were found. The frequencies of AA, GG and AG of IL-4+45 locus in the cases were 55.4%, 10.9%, and 33.7% and in the controls were 62.0%, 11.6%, and 26.4%. The differences between cases and controls were not significant. The frequencies of B1B1, B2B2, and B1B2 of intron3 VNTR locus in the cases were 73.3%, 1.0%, and 25.7% and in the controls were 68.6%, 1.7%, and 29.8%. The differences were not significant. The frequencies of TT, CC, and CT in -33 locus in the cases were 55.4%, 11.9%, and 32.7% and in the controls were 69.4%, 4.1%, and 26.4%. The differences were significant (P=0.034).

Conclusion:

The relationship between genetic polymorphism of IL-4-33 site and silicosis has been found and -33TT is a protective genotype for silicosis.

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