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Updated: May 24, 2026
05:25
Ultrasonography of the Adult Male Urinary Tract for Urinary Functional Testing
Published on: August 14, 2019
Hydroxyfasudil ameliorates bladder dysfunction in male spontaneously hypertensive rats.
Seiya Inoue1, Motoaki Saito, Atsushi Takenaka
1Division of Urology, Tottori University School of Medicine, Yonago, Japan.
Urology
|February 28, 2012
Summary
Hydroxyfasudil improved bladder blood flow in hypertensive rats, ameliorating bladder dysfunction without significantly affecting blood pressure or voiding pressure. This suggests hydroxyfasudil
Area of Science:
- Urology
- Pharmacology
- Cardiovascular Research
Background:
- Hypertension can lead to bladder dysfunction.
- The Rho-associated protein kinase (ROCK) system is implicated in bladder contraction.
- Hydroxyfasudil is a nonselective ROCK inhibitor.
Purpose of the Study:
- To investigate the effects of hydroxyfasudil on hypertension-related bladder dysfunction in spontaneously hypertensive rats (SHRs).
- To explore the role of ROCK in hypertension-induced bladder changes.
Main Methods:
- SHRs were treated with hydroxyfasudil (1 mg/kg) daily for 6 weeks.
- Voiding functions were assessed using metabolic cages and cystometric studies.
- Bladder blood flow (BBF), nerve growth factor (NGF), and ROCK activity were measured.
Main Results:
- SHRs exhibited increased micturition frequency and decreased voided volume.
- Hydroxyfasudil treatment ameliorated these bladder dysfunctions in SHRs.
- BBF and bladder NGF levels were improved by hydroxyfasudil, with minimal impact on blood pressure.
Conclusions:
- Hydroxyfasudil effectively improved bladder blood flow in SHRs.
- The drug ameliorated hypertension-related bladder dysfunction, potentially via BBF enhancement.
- No significant effect on micturition pressure was observed at the tested dose.
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