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Related Concept Videos

Combinatorial Gene Control02:33

Combinatorial Gene Control

Combinatorial gene control is the synergistic action of several transcriptional factors to regulate the expression of a single gene. The absence of one or more of these factors may lead to a significant difference in the level of gene expression or repression.
The expression of more than 30,000 genes is controlled by approximately 2000-3000 transcription factors. This is possible because a single transcription factor can recognize more than one regulatory sequence. The specificity in gene...
Transcription01:10

Transcription

Overview
Transcription is the process of synthesizing RNA from a DNA sequence by RNA polymerase. It is the first step in producing a protein from a gene sequence. Additionally, many other proteins and regulatory sequences are involved in the proper synthesis of messenger RNA (mRNA). Regulation of transcription is responsible for the differentiation of all the different types of cells and often for the proper cellular response to environmental signals.
Transcription Can Produce Different Kinds...
Transcription01:17

Transcription

Transcription is the synthesis of RNA from a DNA sequence by RNA polymerase. It is the first step in producing a protein from a gene sequence. Additionally, many other proteins and regulatory sequences are involved in correctly synthesizing messenger RNA (mRNA). Transcriptional regulation is responsible for the differentiation of different types of cells and often for the proper cellular response to environmental signals.
Transcription Can Produce Different Kinds of RNA Molecules
In eukaryotes,...
Transcription01:10

Transcription

Overview
Transcription is the process of synthesizing RNA from a DNA sequence by RNA polymerase. It is the first step in producing a protein from a gene sequence. Additionally, many other proteins and regulatory sequences are involved in the proper synthesis of messenger RNA (mRNA). Regulation of transcription is responsible for the differentiation of all the different types of cells and often for the proper cellular response to environmental signals.
Transcription Can Produce Different Kinds...
Transcription01:17

Transcription

Transcription is the synthesis of RNA from a DNA sequence by RNA polymerase. It is the first step in producing a protein from a gene sequence. Additionally, many other proteins and regulatory sequences are involved in correctly synthesizing messenger RNA (mRNA). Transcriptional regulation is responsible for the differentiation of different types of cells and often for the proper cellular response to environmental signals.
Transcription Can Produce Different Kinds of RNA Molecules
In eukaryotes,...
From DNA to Protein03:06

From DNA to Protein

The flow of genetic information in cells from DNA to mRNA to protein is described by the central dogma, which states that genes specify the sequence of mRNAs, which in turn specify the sequence of amino acids making up all proteins. The decoding of one molecule to another is performed by specific proteins and RNAs. Because the information stored in DNA is so central to cellular function, it makes intuitive sense that the cell would make mRNA copies of this information for protein synthesis...

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DNA-Tethered RNA Polymerase for Programmable In vitro Transcription and Molecular Computation
09:26

DNA-Tethered RNA Polymerase for Programmable In vitro Transcription and Molecular Computation

Published on: December 29, 2021

Transcription factories: genetic programming in three dimensions.

Lucas Brandon Edelman1, Peter Fraser

  • 1Nuclear Dynamics Laboratory, The Babraham Institute, Babraham Research Campus, Cambridge CB22 3AT, United Kingdom.

Current Opinion in Genetics & Development
|February 28, 2012
PubMed
Summary

Gene expression in eukaryotic cells occurs in specialized nuclear compartments called transcription factories. Recent research explores their molecular makeup and dynamics, revealing new insights into gene regulation and spatial control within the cell nucleus.

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Area of Science:

  • Molecular Biology
  • Cell Biology
  • Genetics

Background:

  • The eukaryotic transcriptional apparatus is crucial for regulated gene expression across diverse cell types.
  • The concept of transcription occurring within discrete nuclear 'transcription factories' is gaining support.
  • Understanding the spatial organization of transcription is key to comprehending gene regulation.

Purpose of the Study:

  • To investigate the molecular constituents of transcription factories.
  • To analyze the dynamical behavior of transcription factories.
  • To identify the organizational regulators of transcription factories.

Main Methods:

  • Application of innovative technical approaches.
  • Analysis of molecular components within the nucleus.
  • Observation of dynamic processes in real-time.

Main Results:

  • Identification of key molecular players within transcription factories.
  • Characterization of the dynamic behavior and assembly of these factories.
  • Elucidation of regulatory mechanisms governing transcription factory organization.

Conclusions:

  • Transcription factories represent a significant organizational principle in eukaryotic gene expression.
  • Spatial organization within the nucleus plays a critical role in transcriptional control.
  • Further research into transcription factories promises deeper understanding of gene regulation.