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Updated: May 24, 2026
07:15
A Mouse Model of Incompletely Resected Soft Tissue Sarcoma for Testing (Neo)adjuvant Therapies
Published on: July 28, 2020
Prognostic factors and staging for soft tissue sarcomas: an update
Natalie B Jones1, Hans Iwenofu, Thomas Scharschmidt
1Department of Surgery, The Ohio State University, Columbus, OH 43210, USA.
Surgical Oncology Clinics of North America
|February 28, 2012
Summary
Soft tissue sarcoma (STS) staging is evolving, with grading crucial for classification. Some STS tumors with uncertain potential require separate staging systems and may not be considered sarcomas.
Area of Science:
- Oncology
- Surgical Pathology
Background:
- Soft tissue sarcoma (STS) staging is a dynamic field.
- Tumor grading remains a critical component in STS classification.
- A three-tier grading system is currently employed.
Purpose of the Study:
- To discuss the complexities of Soft tissue sarcoma (STS) staging.
- To highlight challenges in categorizing STS with uncertain malignant potential.
- To explore the future of STS staging.
Main Methods:
- Review of current STS staging practices.
- Analysis of challenging STS subtypes.
- Discussion of prognostic factors.
Main Results:
- Certain STS, like solitary fibrous tumors, gastrointestinal stromal tumors, and glomus tumors, present classification difficulties.
- These challenging tumors may necessitate distinct staging systems.
- Some of these tumors are debated as true sarcomas.
Conclusions:
- STS staging requires continuous evolution.
- The three-tier grading system is important but insufficient for all STS.
- Future STS staging will likely incorporate novel prognostic factors beyond the TNM system.
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