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Updated: May 24, 2026

Antimicrobial Peptides Produced by Selective Pressure Incorporation of Non-canonical Amino Acids
Published on: May 4, 2018
Three novel cyclic hexapeptides from Streptomyces alboflavus 313 and their antibacterial activity
Zhiqin Ji1, Shaopeng Wei, Lixia Fan
1State Key Laboratory of Crop Stress Biology in Arid Areas, Institute of Pesticide Science, Northwest A & F University, Xinong 61#, Yangling, Shaanxi 712100, PR China. jizhiqin@nwsuaf.edu.cn
Abstract:
Three novel cyclic hexapeptides, designated NW-G05 (1), NW-G06 (2) and NW-G07 (3), were isolated from the fermentation broth of Streptomyces alboflavus 313. Their structures were elucidated on the basis of extensive spectroscopic analysis, MS experiments, and chemical analysis. Their antibacterial activities against several strains of bacteria were evaluated by micro-broth dilution method. Among these compounds, NW-G06 (2) and NW-G07 (3) displayed highly antibacterial activity against gram-positive bacteria, but not gram negative ones. However, NW-G05 (1) was not active against all tested microorganisms.
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