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Related Concept Videos

Allergic Reactions: Anaphylaxis01:30

Allergic Reactions: Anaphylaxis

Anaphylaxis is a severe, life-threatening hypersensitivity reaction mediated by Immunoglobulin E (IgE) antibodies. When IgE binds to allergens, it triggers the release of mediators– histamine, leukotrienes, and prostaglandins from mast cells and basophils. These mediators cause vasodilation, edema, and inflammation, leading to various symptoms.The primary allergens causing anaphylaxis include food items (e.g., peanuts, shellfish), drugs (e.g., penicillin, asparaginase, corticotropin, heparin),...
Allergic Reactions02:06

Allergic Reactions

Overview
Allergic Drug Reactions01:27

Allergic Drug Reactions

Allergic reactions related to drugs are hypersensitivity responses driven by the immune system and bear no connection to the drug's therapeutic action. While drugs in isolation do not trigger an immune response, they can interact with endogenous proteins to form antigens. These antigens stimulate lymphocytes to produce antibodies. IgE-type antibodies attach themselves to mast cells. Upon subsequent exposure to the same stimulus, the antigen-antibody interaction is initiated, unleashing numerous...
Hypersensitivities01:30

Hypersensitivities

Hypersensitivity, also known as a hypersensitivity reaction or allergic reaction, is a condition where the body's immune system reacts abnormally to a foreign substance. Such substances, that cause hypersensitivity are referred to as an allergen, could be something typically harmless to most people, like pollen or certain foods.
Types of Hypersensitivities
Hypersensitivity reactions are categorized into four types: Type 1, Type 2, Type 3, and Type 4. Each type has a distinct mechanism...
Cross-reactivity00:42

Cross-reactivity

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Drug Toxicity: Allergic Reactions01:30

Drug Toxicity: Allergic Reactions

Drug-related allergies are immune-mediated responses triggered by the administration of pharmacological agents. These hypersensitivity reactions are classified based on the immune mechanisms involved. The four primary types—Type I, II, III, and IV—are mediated by different immunological pathways and exhibit distinct clinical manifestations.Type I Hypersensitivity/ IgE-Mediated Reactions: Immunoglobulin E (IgE) immediately mediates Type I hypersensitivity reactions. Upon initial exposure to a...

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Related Experiment Video

Updated: May 24, 2026

Application of Biochip Microfluidic Technology to Detect Serum Allergen-specific Immunoglobulin E (sIgE)
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Application of Biochip Microfluidic Technology to Detect Serum Allergen-specific Immunoglobulin E (sIgE)

Published on: April 21, 2019

ICON: food allergy.

A Wesley Burks1, Mimi Tang, Scott Sicherer

  • 1Department of Pediatrics, University of North Carolina, Chapel Hill, NC, USA. wburks@email.unc.edu

The Journal of Allergy and Clinical Immunology
|February 28, 2012
PubMed
Summary
This summary is machine-generated.

Food allergies are rising globally, causing severe reactions and impacting quality of life. Current management focuses on avoidance and symptom control, as no cure exists for food allergies.

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Area of Science:

  • Immunology
  • Allergology

Background:

  • Food allergies present a growing global health concern, with increasing prevalence worldwide.
  • While over 170 foods can trigger allergies, a few common allergens are responsible for most reactions, varying by region.

Purpose of the Study:

  • To provide a comprehensive overview of the natural history, prevalence, diagnosis, and treatment of food allergies.
  • To support physicians in managing food allergies through globally accessible consensus documents.

Main Methods:

  • Development of International Consensus ON (ICON) documents through a global collaboration.
  • Formation of an author group to synthesize current knowledge on food allergies.

Main Results:

  • Food allergies cause life-threatening reactions and reduce quality of life.
  • Strict avoidance of trigger foods and symptom management are current treatment strategies; no cure is available.

Conclusions:

  • The International Collaboration in Asthma, Allergy and Immunology aims to improve global information exchange on allergies.
  • ICON documents serve as a vital resource for healthcare professionals managing food allergies.