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Controlling angiogenesis in breast cancer: a systematic review of anti-angiogenic trials

John R Mackey1, Robert S Kerbel, Karen A Gelmon

  • 1Cross Cancer Institute, 11560 University Avenue, Edmonton, Alberta, Canada. john.mackey@trioncology.org

Cancer Treatment Reviews
|February 28, 2012
PubMed
Abstract

Insights

Anti-angiogenic agents show promise in breast cancer (BC) treatment, improving progression-free survival but not overall survival. Further research is needed to optimize their use and minimize side effects for selected BC patients.

Area of Science:

  • Oncology
  • Pharmacology

Background:

  • Angiogenesis is crucial for tumor growth and a key therapeutic target in breast cancer (BC).
  • Anti-angiogenic agents aim to inhibit tumor vascularization.

Purpose of the Study:

  • To review and analyze clinical trial data of anti-angiogenic agents for breast cancer treatment.
  • To evaluate the efficacy and safety of these agents in various BC settings.

Main Methods:

  • Systematic search of PubMed and conference databases.
  • Identification of randomized clinical trials investigating anti-angiogenic agents in BC.

Main Results:

  • Bevacizumab improved progression-free survival but not overall survival in advanced BC.
  • Tyrosine kinase inhibitors (sunitinib, sorafenib, pazopanib) showed mixed results with notable side effects.
  • Adverse event rates were higher with bevacizumab-containing regimens.

Conclusions:

  • Anti-angiogenic agents offer improved response rates and progression-free survival in BC but not overall survival.
  • Optimizing therapeutic indices and identifying predictive biomarkers are critical for future development.
  • Combinatorial strategies and ongoing trials are essential for establishing clinical benefits in specific BC populations.

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