Related Experiment Video
Updated: May 24, 2026

The Use of Mouse Splenocytes to Assess Pathogen-associated Molecular Pattern Influence on Clock Gene Expression
Published on: July 24, 2018
Toll-like receptor 9, what o'clock is it?
Hannah-Lena Obermann1, Stefan Bauer
1Institute for Immunology, Philipps-University Marburg, BMFZ, Hans-Meerweinstr. 2, 35043 Marburg, Germany.
The circadian cycle regulates murine Toll-like receptor 9 (TLR9) expression and function. This finding impacts our understanding of innate and adaptive immunity.
Area of Science:
- Immunology
- Chronobiology
- Molecular Biology
Background:
- Toll-like receptor 9 (TLR9) plays a crucial role in immune responses.
- The circadian cycle influences various physiological processes, including immune function.
Discussion:
- This study demonstrates a direct link between the circadian clock and TLR9 activity in mice.
- Circadian control of TLR9 impacts both innate and adaptive immune pathways.
Key Insights:
- Murine TLR9 expression and function are under circadian regulation.
- Immune system's ability to respond to pathogens may vary depending on the time of day.
Outlook:
- Further research could explore therapeutic strategies targeting circadian rhythms to modulate immune responses.
- Investigating similar mechanisms in human TLR9 is warranted.
More Related Videos
09:51Screening Bioactive Nanoparticles in Phagocytic Immune Cells for Inhibitors of Toll-like Receptor Signaling
Published on: July 26, 2017
07:55A Macrophage Reporter Cell Assay to Examine Toll-Like Receptor-Mediated NF-kB/AP-1 Signaling on Adsorbed Protein Layers on Polymeric Surfaces
Published on: January 7, 2020
Related Concept Videos
lncRNA - Long Non-coding RNAs
Receptor Tyrosine Kinases
Calmodulin-dependent Signaling
The Ca2+-CaM complex does not have enzymatic activity by itself. Instead, the complex binds downstream target proteins, including membrane proteins or enzymes,...
Transducer Mechanism: Enzyme-Linked Receptors
Major types that are helpful drug targets include:
G-protein Coupled Receptors
G-protein Coupled Receptors