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Decreased Body Temperature01:29

Decreased Body Temperature

A decreased body temperature can occur in patients with hypothermia and frostbite. Heat loss with extended cold exposure overpowers the body's ability to create heat, resulting in hypothermia. Core temperature readings help classify hypothermia. Mild hypothermia is temperatures between 32 °C (89.6 °F) and 35°C (95 °F) and is caused by impaired thermoregulation. Moderate hypothermia is temperatures between 28 C (82.4 °F) and 32 °C (89.6 °F) caused by sustained extreme cold exposure, and severe...
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Short-Duration Hypothermia Induction in Rats using Models for Studies examining Clinical Relevance and Mechanisms
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Deep hypothermia terminates status epilepticus--an experimental study.

Alexander B Kowski1, Hassan Kanaan, Friedhelm C Schmitt

  • 1Department of Neurology, Charité, Universitätsmedizin Berlin, Germany. alexander.kowski@charite.de

Brain Research
|February 28, 2012
PubMed
Summary

Deep hypothermia (cooling to 20 °C) effectively suppressed status epilepticus (SE) in a rodent model, with seizure activity not recurring upon rewarming. This suggests cooling is a safe and potent non-pharmacological treatment for refractory SE.

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Area of Science:

  • Neuroscience
  • Pharmacology
  • Critical Care Medicine

Background:

  • Status epilepticus (SE) is a neurological emergency requiring effective treatments.
  • Current treatments for SE can be limited, necessitating novel therapeutic approaches.
  • Hypothermia has shown potential anticonvulsant effects in preliminary studies.

Purpose of the Study:

  • To evaluate the anticonvulsant efficacy of moderate and deep hypothermia in a rodent model of self-sustaining status epilepticus (SSSE).
  • To assess the safety and enduring effects of hypothermia treatment during and after rewarming.

Main Methods:

  • Self-sustaining status epilepticus (SSSE) was induced in adult male rats via electrical stimulation.
  • Rats were cooled to 30 °C or 20 °C for 120 minutes, followed by rewarming to 37 °C.
  • Control rats remained untreated; epileptiform discharge frequency was monitored throughout.

Main Results:

  • Deep hypothermia (20 °C) completely suppressed SSSE in 4 out of 10 rats, a statistically significant effect (p=0.043).
  • Discharge frequency was significantly lower in the 20 °C group post-cooling.
  • No seizure recurrence was observed upon rewarming, and all animals survived deep hypothermia.

Conclusions:

  • Deep hypothermia (20 °C) demonstrates strong, enduring anticonvulsant properties in a rodent model of SE.
  • Cooling to 20 °C appears safe, with all treated animals surviving and recovering motor function.
  • Deep cooling presents a promising non-pharmacological adjunct therapy for patients with refractory status epilepticus.