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Related Concept Videos

Disorders of Leukocytes01:27

Disorders of Leukocytes

Leukocyte disorders can lead to either leukopenia, characterized by an abnormally low leukocyte count, or leukocytosis, marked by a very high leukocyte number.
Leukopenia may result from bone marrow disorders, autoimmune diseases, and infectious diseases. For example, conditions such as multiple myeloma and aplastic anemia can impair the bone marrow's ability to produce adequate leukocytes. Similarly, autoimmune diseases like lupus and viral infections such as HIV can prompt the immune system...
Bone Disorders01:29

Bone Disorders

Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Bone Marrow Sampling and Transplants01:22

Bone Marrow Sampling and Transplants

Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
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Cytotoxic Edema: Pathophysiology01:21

Cytotoxic Edema: Pathophysiology

Cytotoxic edema is a form of cerebral edema characterized by intracellular swelling of neurons, astrocytes, and other glial cells. It develops when the mechanisms responsible for maintaining ionic gradients across the cell membrane become impaired. Under normal physiological conditions, the sodium–potassium ATPase actively transports sodium ions out of the cell and potassium ions into the cell, preserving osmotic balance and enabling electrical signaling. This pump requires a continuous supply...
Cushing Syndrome II: Pathophysiology01:19

Cushing Syndrome II: Pathophysiology

Cortisol production is normally governed by the hypothalamic–pituitary–adrenal (HPA) axis, which maintains hormonal balance through tightly regulated feedback mechanisms. Disruption of this regulatory system is central to the development of Cushing syndrome, whether the excess cortisol originates from external medications or internal pathology. Persistent cortisol elevation alters metabolism, immune function, and endocrine signaling, producing the characteristic clinical features of the...
Cranial and Spinal Meninges01:19

Cranial and Spinal Meninges

The cranial and spinal meninges are complex protective structures surrounding the central nervous system (CNS), consisting of the brain and spinal cord. These meninges consist of the dura mater, the arachnoid mater, and the pia mater. They protect the CNS, provide structural support, and aid in circulating cerebrospinal fluid (CSF).
Cranial Meninges
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Analyzing the Functions of Mast Cells In Vivo Using 'Mast Cell Knock-in' Mice
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Published on: May 27, 2015

Ivory vertebra and systemic mastocytosis.

Laurent Frenzel1, Felipe Suarez, Marie-Olivia Chandesris

  • 1Service d'hématologie adulte, centre de référence des mastocytoses, hôpital Necker-Enfants-Malades, 149, rue de Sèvres, 75743 Paris cedex 15, France. laurent.frenzel@nck.aphp.fr

Joint Bone Spine
|February 28, 2012
PubMed
Summary

The ivory vertebra sign, often indicating metastasis or lymphoma, can rarely be caused by systemic mastocytosis. Early diagnosis and treatment of systemic mastocytosis can improve this bone finding.

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Area of Science:

  • Radiology
  • Oncology
  • Hematology

Background:

  • The ivory vertebra sign on spinal radiographs typically suggests malignancy, lymphoma, or Paget's disease.
  • Idiopathic ivory vertebra is diagnosed when no underlying cause is found.
  • Systemic mastocytosis commonly causes osteoporosis but can present with focal bone lesions.

Observation:

  • This report details an unusual case where the ivory vertebra sign was the primary manifestation of systemic mastocytosis.
  • The patient's ivory vertebra sign showed improvement following specific treatment for systemic mastocytosis.

Findings:

  • Systemic mastocytosis should be considered in the differential diagnosis of an ivory vertebra sign.
  • An isolated sclerotic or lytic bone lesion can be a presenting feature of systemic mastocytosis.
  • Effective treatments are available for systemic mastocytosis, highlighting the importance of diagnosis.

Implications:

  • The ivory vertebra sign should not be presumed idiopathic without ruling out systemic mastocytosis.
  • Investigating systemic mastocytosis in patients with ivory vertebrae can lead to timely and effective treatment.
  • This case broadens the understanding of bone manifestations in systemic mastocytosis.