Related Experiment Video
Updated: May 24, 2026
Preparation and Characterization of Novel HDL-mimicking Nanoparticles for Nerve Growth Factor Encapsulation
Published on: May 22, 2017
Preparation and characterization of recombinant human growth hormone-Zn2+-dextran nanoparticles using aqueous
Weien Yuan1, Zhenhua Hu, Jing Su
1Department of Neurology, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China. yuanweien@126.com
Abstract:
An effective and simple method was developed to prepare spherical and uniform-sized recombinant human growth hormone (rhGH)-Zn(2+)-dextran nanoparticles (NPs) for a variety of delivery applications of the delicate protein. The results showed that the prepared rhGH-Zn(2+)-dextran particles were spherical, glassy, and uniform in size. rhGH recovered from the NPs maintained its structural integrity and its bioactivity well, as suggested by the Nb(2)-11 cell proliferation assay. Using polyethylene glycol and polysaccharide to mediate Zn(2+)-induced precipitation has proved to be a promising method to prepare spherical protein-loaded NPs with desired sizes and preserved protein stability.
From The Clinical Editor:
This basic science paper discusses a simple yet effective method to prepare spherical and uniform-sized recombinant human growth hormone (rhGH)-Zn(2+)-dextran nanoparticles for a variety of delivery applications.
