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Updated: May 24, 2026

Ferric Chloride-induced Murine Thrombosis Models

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Published on: September 5, 2016

Total steroidal alkaloids from Veratrum patulum L. Inhibit platelet aggregation, thrombi formation and decrease

Qiling Song¹, Shisheng Wang, Weijie Zhao

¹School of Pharmaceutical Science and Technology, Dalian University of Technology, No. 2 Linggong Road, Ganjingzi District, Dalian City, Liaoning Province 116024, PR China.

Journal of Ethnopharmacology

|February 28, 2012

Summary

This summary is machine-generated.

Total steroidal alkaloids from Veratrum patulum L. (VpA) effectively inhibit arterial and venous thrombosis by reducing platelet aggregation, particularly collagen-induced aggregation. This study highlights VpA

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Published on: March 17, 2023

Area of Science:

Pharmacology
Natural Products Chemistry
Cardiovascular Research

Background:

Veratrum patulum L. (Liliaceae), a source of traditional Chinese medicine "Lilu", has a long history of use for various ailments.
Its traditional applications include treating apoplexy-induced aphasia, dysentery, and headaches.

Purpose of the Study:

To investigate the antithrombotic potential of total steroidal alkaloids from Veratrum patulum L. (VpA).
To elucidate the underlying mechanisms of VpA's antithrombotic activity.

Main Methods:

Evaluation of VpA's antithrombotic effects in rat models of arterial and venous thrombosis.
Assessment of VpA's impact on coagulation parameters and platelet aggregation.
Determination of VpA's effect on bleeding time using a cutting-tail rat model.

Main Results:

VpA significantly inhibited both arterial and venous thrombosis formation in rats.
VpA demonstrated potent inhibition of platelet aggregation, with effectiveness in the order of collagen > ADP > thrombin.
No significant influence of VpA on coagulation parameters was observed, but it reduced bleeding time.

Conclusions:

VpA exhibits significant antithrombotic effects against both venous and arterial thrombosis.
The antithrombotic action of VpA is primarily attributed to its ability to inhibit platelet aggregation, especially that induced by collagen.