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Antiulcer principle from Zingiber montanum
Mohammad Al-Amin1, Gazi Nurun Nahar Sultana, Chowdhury Faiz Hossain
1Department of Pharmacy, East West University, 43 Mohakhali C/A, Dhaka 1212, Bangladesh.
Journal of Ethnopharmacology
|February 28, 2012
Summary
Zerumbone, isolated from Zingiber montanum rhizomes, demonstrates significant antiulcer properties. This natural compound effectively protects against gastric lesions induced by HCl, ethanol, and indomethacin in mice.
Area of Science:
- Pharmacology
- Natural Product Chemistry
- Gastroenterology
Background:
- Zingiber montanum rhizome is a traditional Bangladeshi remedy for peptic ulcers.
- This study investigates the scientific basis for its traditional use.
Purpose of the Study:
- To isolate and identify the antiulcer compound from Zingiber montanum rhizome extract.
- To elucidate the structure of the isolated compound using spectroscopic methods.
- To evaluate the antiulcer activity of the purified compound.
Main Methods:
- Methanolic extract of Zingiber montanum rhizomes was prepared.
- Antiulcer activity was assessed using 1N HCl, 95% ethanol, and indomethacin-induced gastric lesion models in mice.
- Bioassay-guided fractionation, chromatography, and crystallization were employed for compound isolation.
- Spectroscopic methods were used for structure elucidation.
Main Results:
- The methanolic extract showed significant inhibition of gastric lesions.
- Fraction 2 exhibited potent antiulcer activity.
- Zerumbone was isolated and identified as the active antiulcer principle.
- Zerumbone demonstrated dose-dependent inhibition of gastric lesions induced by HCl, ethanol, and indomethacin.
Conclusions:
- Zerumbone possesses significant cytoprotective effects against various gastric ulcerogenic agents.
- It shows promise as a novel natural drug lead for antiulcer therapy.
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