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Related Concept Videos

Sleep Apnea01:21

Sleep Apnea

Sleep apnea is a condition where breathing stops intermittently during sleep, often leading to significant health issues. Each episode can last from 10 to 20 seconds or more and is frequently accompanied by a brief arousal from sleep. This disturbance, largely unnoticed by the individual, can lead to severe daytime fatigue. Commonly, individuals seek help after being informed by their partners about loud snoring and noticeable breathing pauses during sleep.
The condition is more prevalent among...
Mechanical Ventilation III: Noninvasive Ventilation01:23

Mechanical Ventilation III: Noninvasive Ventilation

Noninvasive positive-pressure ventilation (NIPPV), continuous positive airway pressure (CPAP), and bilevel positive airway pressure (BiPAP) are essential methods in respiratory care. These ventilation techniques offer unique benefits for patients with various respiratory conditions, providing adequate support without requiring intubation. Let's explore how each method is crucial in improving patient outcomes and enhancing respiratory therapy.
Noninvasive Positive-Pressure Ventilation (NIPPV)
Cardiopulmonary Resuscitation V: Advanced Airway Management Techniques01:30

Cardiopulmonary Resuscitation V: Advanced Airway Management Techniques

Airway management is essential in emergency and surgical medicine, ensuring ventilation and oxygenation in patients who cannot maintain their own airway. Clinicians use a range of techniques and devices to secure the airway, depending on the patient’s condition and the clinical context. Key methods include endotracheal intubation, rapid sequence intubation (RSI), supraglottic airway devices, and advanced visualization aids. In cases where these approaches fail, surgical airway interventions are...
Cardiopulmonary Resuscitation II: ACLS Airway Management01:22

Cardiopulmonary Resuscitation II: ACLS Airway Management

Airway management is a key skill in emergency and critical care settings, as maintaining a clear airway is essential for adequate oxygenation and ventilation.Head Tilt-Chin Lift TechniqueThe head tilt-chin lift maneuver is an essential technique primarily used in patients without suspected cervical spine injuries. To perform this maneuver, one hand is placed on the patient’s forehead, and gentle pressure is applied backward to tilt the head. The fingertips of the other hand are positioned under...
Treatment for Pulmonary Arterial Hypertension: Oxygen Therapy for Respiratory Failure01:16

Treatment for Pulmonary Arterial Hypertension: Oxygen Therapy for Respiratory Failure

Oxygen therapy has emerged as a significant tool in enhancing the quality of life for patients suffering from pulmonary arterial hypertension (PAH). While this therapy has principally been studied on patients with significant hypoxemia, this therapeutic approach helps prevent potential organ damage and can be administered in the comfort of one's home.
Oxygen therapy is vital in increasing and maintaining blood oxygen levels in PAH patients. As a result, it aids in reducing fatigue, improving...
Chronic Obstructive Pulmonary Disease-V: Management01:29

Chronic Obstructive Pulmonary Disease-V: Management

Managing Chronic Obstructive Pulmonary Disease (COPD) involves a multifaceted approach to reduce symptoms, prevent exacerbations, improve overall health status, and slow disease progression. Key strategies include lifestyle modifications, pharmacotherapy, supportive therapies, and, in some cases, surgery. Here is an overview of the primary COPD management strategies:
Smoking Cessation

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Related Experiment Video

Updated: May 24, 2026

Drug-Induced Sleep Endoscopy (DISE) with Target Controlled Infusion (TCI) and Bispectral Analysis in Obstructive Sleep Apnea
07:54

Drug-Induced Sleep Endoscopy (DISE) with Target Controlled Infusion (TCI) and Bispectral Analysis in Obstructive Sleep Apnea

Published on: December 6, 2016

Emerging therapies for obstructive sleep apnea.

Morohunfolu Akinnusi1, Ranime Saliba, Ali A El-Solh

  • 1The Veterans Affairs Western New York Healthcare System, Buffalo, NY 14215-1199, USA.

Lung
|February 28, 2012
PubMed
Summary

New therapies for obstructive sleep apnea (OSA) show promise. Electrical stimulation and nasal resistance devices may offer alternatives, but patient response varies, requiring further study.

Area of Science:

  • Sleep Medicine
  • Otolaryngology
  • Neuromodulation

Background:

  • Obstructive sleep apnea (OSA) is a common condition linked to serious health issues like cardiovascular disease and cognitive impairment.
  • Current OSA treatments face challenges with patient adherence and effectiveness.
  • Novel therapeutic approaches are needed to improve patient outcomes.

Purpose of the Study:

  • To review emerging treatments for obstructive sleep apnea (OSA).
  • To evaluate the potential of genioglossus muscle electrical stimulation and nasal expiratory resistance devices.
  • To discuss the efficacy and limitations of these new OSA therapies.

Main Methods:

  • Review of phase I and II clinical trial data for two novel OSA therapies.
  • Assessment of upper-airway stimulation via genioglossus muscle electrical stimulation.

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  • Evaluation of a nasal device designed to increase expiratory nasal resistance.

    • Main Results:

    • Electrical stimulation of the genioglossus muscle showed potential in improving upper-airway diameter and reducing pharyngeal obstruction, with variable apnea-hypopnea index improvements.
    • The nasal expiratory resistance device demonstrated reductions in sleep apnea severity and daytime sleepiness, despite noted heterogeneity in patient response.
    • High adherence rates were observed for the nasal device, but long-term safety data for both methods are pending.

    Conclusions:

    • Emerging therapies like genioglossus muscle electrical stimulation and nasal expiratory resistance devices offer potential new avenues for OSA management.
    • Significant variability in individual patient response to these novel treatments was observed.
    • Further research is necessary to determine long-term safety, efficacy, and patient selection criteria for these promising OSA interventions.