Related Experiment Video
Updated: May 24, 2026
07:20
Human Skeletal Muscle Biopsy Procedures Using the Modified Bergström Technique
Published on: September 10, 2014
Nutrient interaction for optimal protein anabolism in resistance exercise
Leigh Breen1, Stuart M Phillips
1Department of Kinesiology, McMaster University, Hamilton, Ontario, Canada.
Current Opinion in Clinical Nutrition and Metabolic Care
|February 28, 2012
Summary
Exercise and nutrition can help combat muscle loss in cachexia. Lower-load resistance training and specific protein intake stimulate muscle protein synthesis, offering practical strategies for affected populations.
Area of Science:
- Exercise Physiology
- Nutritional Science
- Muscle Metabolism
Background:
- Cachexia involves an imbalance between muscle protein synthesis (MPS) and breakdown, leading to rapid muscle loss.
- Traditional approaches to stimulate MPS in cachexia may be suboptimal for affected individuals.
Purpose of the Study:
- To review current evidence on exercise and nutrient interventions for cachectic populations.
- To provide practical recommendations for managing muscle loss in disease states.
Main Methods:
- Review of recent scientific literature on resistance exercise and protein supplementation.
- Analysis of studies investigating varying exercise loads and protein dosages.
Main Results:
- Lower-load resistance exercise effectively stimulates MPS and hypertrophy, contrary to previous assumptions.
- Protein ingestion enhances resistance exercise-induced MPS, with rapidly digested, leucine-rich sources being particularly effective.
- Optimal amino acid dosage for MPS response varies, with sarcopenic elderly individuals benefiting from higher doses than young adults.
Conclusions:
- Manipulating exercise intensity and nutrient strategies shows promise in ameliorating cachexia.
- Evidence supports tailored exercise and nutritional interventions for cachectic individuals.
More Related Videos
Related Concept Videos
01:28Proteins: Dietary Sources and Requirements
Consuming animal-based products offers high-quality proteins that contain optimal levels and combinations of essential amino acids, crucial for tissue repair and growth. Foods like eggs, milk, fish, and most meats are a source of complete proteins. Legumes and cereals are abundant in proteins; however, they typically lack a full range of essential amino acids. As a result, they are considered incomplete protein sources. Some plant sources like soybeans, quinoa, and amaranth do contain complete...
01:21Overview of Protein Metabolism
Proteins are broken down into amino acids during digestion. Unlike fats and carbohydrates, which are stored for later use, proteins are not. Instead, amino acids are either used to produce ATP through oxidation or contribute to the creation of new proteins for the growth and repair of the body. Any surplus amino acids from the diet are converted into glucose or triglycerides rather than excreted.
Amino acids play various roles in the body once they are absorbed into cells. They are restructured...
Amino acids play various roles in the body once they are absorbed into cells. They are restructured...
01:27Exercise and Muscle Performance
Exercise induces a range of adaptations in muscle tissue, depending on the type and duration of activity. Such physical training can be broadly categorized into two types: endurance exercises and resistance exercises.
Endurance exercises
Endurance exercises involve running, swimming, or cycling, which require repetitive movements with low force output. When a person engages in endurance exercise, a few noticeable changes occur in their skeletal muscles. For instance, the number of capillaries...
Endurance exercises
Endurance exercises involve running, swimming, or cycling, which require repetitive movements with low force output. When a person engages in endurance exercise, a few noticeable changes occur in their skeletal muscles. For instance, the number of capillaries...
01:18Amino Acid Catabolism
Microorganisms rely on proteins as an essential carbon and energy source, particularly in environments with limited polysaccharides or lipids. However, proteins are too large to cross the plasma membrane unaided, necessitating enzymatic degradation. Microbes secrete extracellular proteases and peptidases that hydrolyze proteins into peptides, which can then be transported across the membrane. Once inside the cell, intracellular proteases degrade these peptides into free amino acids, which...
02:26Protein Networks
An organism can have thousands of different proteins, and these proteins must cooperate to ensure the health of an organism. Proteins bind to other proteins and form complexes to carry out their functions. Many proteins interact with multiple other proteins creating a complex network of protein interactions.
These interactions can be represented through maps depicting protein-protein interaction networks, represented as nodes and edges. Nodes are circles that are representative of a protein,...
These interactions can be represented through maps depicting protein-protein interaction networks, represented as nodes and edges. Nodes are circles that are representative of a protein,...
01:19Regulation of Metabolism
Cellular needs and conditions vary from cell to cell and change within individual cells over time. For example, the required enzymes and energetic demands of stomach cells are different from those of fat storage cells, skin cells, blood cells, and nerve cells. Furthermore, a digestive cell works much harder to process and break down nutrients during the time that closely follows a meal compared with many hours after a meal. As these cellular demands and conditions vary, so do the amounts and...