Related Experiment Video
Updated: May 24, 2026
Three Different Protocols of Corneal Collagen Crosslinking in Keratoconus: Conventional, Accelerated and Iontophoresis
Published on: November 12, 2015
Comparison of central corneal thickness and anterior chamber depth measured using LenStar LS900, Pentacam, and
Clare OʼDonnell1, Andreas Hartwig, Hema Radhakrishnan
1Optegra Eye Sciences, Optegra Manchester Eye Hospital, Manchester, United Kingdom.
Purpose:
To compare central corneal thickness (CCT) and anterior chamber depth (ACD) measured using 3 different techniques.
Methods:
CCT and ACD were measured in one eye of 27 healthy subjects (age, mean ± SD: 34 ± 7 years), using the LenStar LS900, Pentacam, and Visante AS-OCT. The agreement between the measurement techniques was assessed using the coefficient of agreement (CoA) and the 95% limits of agreement (LoA).
Results:
Mean ± SD values for CCT using the LenStar, Pentacam, and Visante were 550.7 ± 37.4 μm, 542.7 ± 37.9 μm, and 556.7 ± 44.4 μm, respectively (P = 0.005). Plots of differences against means displayed relatively good agreement between the Pentacam and LenStar (CoA, 19.97 μm; LoA, 15.53 μm to -24.40 μm), poorer agreement between the LenStar and Visante (CoA, 31.26 μm; LoA, 40.78 μm to -21.74 μm), and agreement was poor between the Pentacam and Visante (CoA, 37.36 μm; LoA, 25.61 μm to -49.11 μm). Mean ± SD values for ACD using the LenStar, Pentacam, and Visante were 2.93 ± 0.30 mm, 2.96 ± 0.32 mm, and 3.03 ± 0.29 mm, respectively (P < 0.001). Relatively good agreement for ACD measures was observed between the Pentacam and LenStar (CoA, 0.08 mm; LoA, 0.12 to -0.04 mm), poor agreement was obtained between the Visante and LenStar (CoA, 0.13 mm; LoA, 0.21 to -0.06 mm), and agreement was also poor between the Pentacam and Visante (CoA, 0.14 mm; LoA, 0.11 to -0.17 mm).
Conclusions:
Our data show that the LenStar, Pentacam, and Visante provide measurements that are in agreement with published values for CCT and ACD in human subjects. Although reasonable agreement for CCT and ACD was found between the Pentacam and LenStar, agreement was poorer between the Visante and LenStar and between the Visante and Pentacam. Thus, CCT and ACD measures from these instruments should not be used interchangeably.
