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Bridging the Bio-Electronic Interface with Biofabrication
16:38

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Published on: June 6, 2012

Biomolecule immobilization techniques for bioactive paper fabrication.

Fanzhi Kong1, Yim Fun Hu

  • 1School of Engineering, Design and Technology, University of Bradford, Bradford, UK. f.kong@bradford.ac.uk

Analytical and Bioanalytical Chemistry
|February 28, 2012
PubMed
Summary

Bioactive paper, functional materials with recognition capabilities, are advancing for health hazard detection. This review compares biomolecule immobilization techniques for paper-based biosensors and their diverse applications.

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Area of Science:

  • Materials Science
  • Biotechnology
  • Analytical Chemistry

Background:

  • Paper-based sensors are rapidly expanding for analytical functions with active recognition.
  • Significant research focuses on fabricating bioactive paper for biosensor applications to detect health hazards.

Purpose of the Study:

  • To review and compare different biomolecule immobilization techniques for bioactive paper fabrication.
  • To discuss current, emerging, and future applications of bioactive paper.

Main Methods:

  • Immobilization methods are categorized into physical absorption, bioactive ink entrapment, bioaffinity attachment, and covalent chemical bonding.
  • The bioactive ink entrapment method is highlighted for its general applicability and biocompatibility.

Main Results:

  • Each immobilization method possesses unique characteristics requiring optimization for specific biomolecule-paper combinations.
  • Bioactive paper has diverse applications including bioassays, counterfeiting detection, pathogen monitoring, and antimicrobial uses.

Conclusions:

  • Bioactive paper fabrication relies heavily on effective biomolecule immobilization techniques.
  • The field is rapidly evolving with significant potential in various industrial and health-related sectors.