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Diagonal Method to Measure Synergy Among Any Number of Drugs
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Two is company, three is a crowd.

Prabhat Hebbar1, Abhishek Deshmukh, Sadip Pant

  • 1Division of Cardiovascular Medicine, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.

Journal of Cardiovascular Medicine (Hagerstown, Md.)
|February 28, 2012
PubMed
Summary
This summary is machine-generated.

Superior Vena Cava (SVC) syndrome, previously linked to malignancy, is now frequently caused by intravascular devices like pacemakers and central venous catheters (CVC). This case highlights SVC syndrome in a young patient with a pacemaker who received a CVC.

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Area of Science:

  • Cardiology
  • Vascular Surgery
  • Medical Device Technology

Background:

  • Superior Vena Cava (SVC) syndrome is a clinical condition often associated with malignant tumors.
  • The incidence of SVC syndrome has shifted, with intravascular devices now accounting for a significant proportion of cases.
  • Pacemakers and implantable cardioverter-defibrillators (ICDs) are increasingly implicated in SVC syndrome.

Observation:

  • A young patient with a history of permanent pacemaker implantation presented with SVC syndrome.
  • The patient underwent central venous catheter (CVC) placement prior to surgery for hypertrophic cardiomyopathy.
  • This case underscores the potential complications associated with indwelling vascular devices.

Findings:

  • The patient's presentation of SVC syndrome was linked to the presence of both a pacemaker and a recently placed CVC.
  • This case illustrates a non-malignant etiology of SVC syndrome in a patient with multiple intravascular devices.
  • The temporal relationship between device placement and symptom onset suggests a causal link.

Implications:

  • Clinicians should maintain a high index of suspicion for SVC syndrome in patients with pacemakers or CVCs, even in the absence of malignancy.
  • Early recognition and management of device-related SVC syndrome are crucial for patient outcomes.
  • Further research into preventative strategies and optimal management of device-associated SVC syndrome is warranted.