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Updated: May 24, 2026
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Bio-energetics Investigation of Candida albicans Using Real-time Extracellular Flux Analysis
Published on: March 19, 2019
Fructose-1,6-bisphosphate reduces the mortality in Candida albicans bloodstream infection and prevents the
Roberto Christ Vianna Santos1, Rafael Noal Moresco, Miguel Angel Peña Rico
1Laboratório de Microbiologia Clínica, Ciências da Saúde, Centro Universitário Franciscano, UNIFRA, Rua dos Andradas 1614, sala 115, 97010-032, Santa Maria, Rio Grande do Sul, Brazil. roberto@unifra.br
Inflammation
|February 28, 2012
Summary
Fructose-1,6-bisphosphate (FBP) significantly reduced mortality in experimental Candida albicans bloodstream infections. This high-energy metabolite also prevented a decrease in platelet counts, offering a potential therapeutic strategy.
Area of Science:
- Mycology
- Immunology
- Pharmacology
Background:
- Candida species bloodstream infections are a growing concern with high mortality rates.
- Fructose-1,6-bisphosphate (FBP), a glycolytic metabolite, shows therapeutic potential in various conditions.
- There is a need for novel strategies to combat Candida bloodstream infections.
Purpose of the Study:
- To investigate the efficacy of FBP in an experimental model of Candida albicans bloodstream infection.
- To assess the impact of FBP on hematological parameters and cytokine profiles during infection.
Main Methods:
- A mouse model of Candida albicans bloodstream infection was established.
- Mice were divided into sham, infection, and FBP treatment groups (500 mg/kg i.p.).
- Hematological profiles and cytokine levels (IL-6, MCP-1) were analyzed.
Main Results:
- FBP treatment significantly decreased mortality in infected mice.
- Most hematological and cytokine markers remained similar between infection and FBP groups.
- FBP administration notably prevented the reduction in platelet counts observed during infection.
Conclusions:
- Fructose-1,6-bisphosphate (FBP) demonstrates a protective effect against mortality in experimental Candida albicans bloodstream infections.
- FBP's ability to preserve platelet counts suggests a specific mechanism of action.
- FBP represents a promising therapeutic candidate for managing Candida bloodstream infections.
