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Autoimmune polyendocrine syndrome-3 in a patient with late-onset multiple sclerosis
Hiroaki Yokote1, Miki Nagasawa, Masahiko Ichijo
1Department of Neurology, Musashino Red Cross Hospital, Kyonan-cho, Musashino, Tokyo, Japan.
Abstract:
We present here the rare case of a 73-year-old patient with very late-onset multiple sclerosis who developed autoimmune polyendocrine syndrome (APS)-3. Despite only a few reports describing the association between multiple sclerosis and APS, both of these diseases have been shown to be associated with HLA-DR4. Intriguingly, the HLA genotype profile of this patient included HLA-DR4 which, fine mapped to the DRB1*0405-DQA1*0303-DQB1*0401 extended haplotype, reported to be a susceptibility haplotype for APS-3 in Japan. This unique genetic background might explain the clinical picture of this patient.
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