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Related Concept Videos

Drug Discovery: Overview01:26

Drug Discovery: Overview

Drug discovery is a multifaceted process involving extensive screening, testing, and optimization of lead compounds to identify potential new drugs for therapeutic use. It combines several approaches, including screening large numbers of natural products, chemical modification of known active molecules, identification of new drug targets, and rational design based on biological mechanisms and drug-receptor structure. These approaches are carried out in both academic research laboratories and...
Structure-Activity Relationships and Drug Design01:28

Structure-Activity Relationships and Drug Design

Drug design is a dynamic field that involves discovering and developing new medications based on specific biological targets. This process heavily relies on structure-activity relationships (SAR) and quantitative structure-activity relationships (QSAR) to guide the design and optimization of efficient drugs.
SAR studies the intricate relationship between a drug's chemical structure and biological activity. It focuses on understanding how modifications to a drug's structure can influence its...
Preclinical Development: Overview01:28

Preclinical Development: Overview

Preclinical development consists of a series of tests that ensure the safety and efficacy of a new therapeutic compound before it is tested in humans. There are four main phases to this process. First, safety pharmacology tests are conducted to ensure the drug does not produce any acutely harmful effects. These tests examine parameters such as bronchoconstriction, cardiac dysrhythmias, blood pressure changes, and ataxia. Next, preliminary toxicological testing is performed to determine the...
Prodrugs01:30

Prodrugs

Prodrugs are a class of pharmaceutical compounds that undergo a biotransformation process within the body to be converted into a pharmacologically active drug. Prodrugs are designed to improve the therapeutic properties of the parent drug, such as enhancing bioavailability, increasing stability, or reducing toxicity. The concept of prodrugs revolves around modifying the chemical structure of the original drug to make it more effective or convenient for administration.
Prodrugs help overcome...
Pharmacogenomics: Identification of New Drug Targets01:29

Pharmacogenomics: Identification of New Drug Targets

Advances in genomics have profoundly influenced drug discovery by increasing both the speed and accuracy of pharmaceutical development. Pharmacogenomics, which examines how genetic variation influences drug response, facilitates the identification of novel therapeutic targets and enables patient stratification for personalized treatment. These strategies contribute to improved drug efficacy, minimized adverse effects, and more efficient clinical trial design.Mapping genetic differences...
Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches01:23

Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches

Biopharmaceutical studies constitute a vital field aiming to enhance drug delivery methods and refine therapeutic approaches, drawing upon diverse interdisciplinary knowledge. In research methodologies, the choice between controlled and non-controlled studies significantly influences the study's reliability and accuracy.
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast, controlled...

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Updated: May 24, 2026

Drug Repurposing Hypothesis Generation Using the "RE:fine Drugs" System
05:10

Drug Repurposing Hypothesis Generation Using the "RE:fine Drugs" System

Published on: December 11, 2016

Drug Repurposing from an Academic Perspective.

Tudor I Oprea1, Julie E Bauman, Cristian G Bologa

  • 1Division of Biocomputing, Department of Biochemistry and Molecular Biology, University of New Mexico School of Medicine, MSC11 6145, Albuquerque, NM 87131, USA.

Drug Discovery Today. Therapeutic Strategies
|February 28, 2012
PubMed
Summary
This summary is machine-generated.

Academic drug repurposing offers advantages like translational focus but faces challenges in pharmaceutical sciences and regulatory processes. Streamlining regulations and knowledge transfer can bridge the gap between basic and clinical research.

Related Experiment Videos

Last Updated: May 24, 2026

Drug Repurposing Hypothesis Generation Using the "RE:fine Drugs" System
05:10

Drug Repurposing Hypothesis Generation Using the "RE:fine Drugs" System

Published on: December 11, 2016

Area of Science:

  • Drug discovery and development
  • Translational research
  • Pharmaceutical sciences

Background:

  • Academia and small businesses are increasingly involved in drug discovery, particularly drug repurposing.
  • Drug repurposing leverages existing drugs for new therapeutic indications, offering a potentially faster and more cost-effective discovery pathway.

Purpose of the Study:

  • To summarize the project status of various drugs undergoing repurposing research.
  • To discuss the strengths and weaknesses of academic-based drug repurposing initiatives.
  • To propose improvements for academic drug discovery and repurposing processes.

Main Methods:

  • Review of multi-year, multi-project experience in academic drug repurposing.
  • Analysis of strategic advantages (translational, target, disease foci) and drawbacks (pharmaceutical sciences integration, intellectual property, dosing, safety).

Main Results:

  • Academic research offers strategic advantages through close collaboration between basic and clinical scientists, leading to novel drug mechanisms.
  • Weaknesses include insufficient integration with pharmaceutical sciences, inadequate intellectual property protection, and challenges in dosing and safety assessment.

Conclusions:

  • Academic drug repurposing benefits from translational and disease-specific expertise but requires better integration with pharmaceutical sciences and regulatory support.
  • Recommendations include streamlining global regulatory processes and establishing pre-competitive knowledge transfer systems, such as a global healthcare database, to overcome the "valley of death" in drug development.