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Published on: May 3, 2021
[The correlation between the level of serum VEGF and bFGF with metastasis and prognosis of osteosarcoma]
Guo-li Chen1, Hai-bin Lin, Xian-wei Wu
1Department of Clinical Medicine, Medical College of Putian University, Putian 351100, China. ggllchen@163.com
Aim:
To investigate the correlation between the level of serum VEGF and bFGF with metastasis and re- currence of osteosarcoma.
Methods:
52 patients with osteosarcoma and 60 healthy people as control group were selected. The serum contents of VEGF and bFGF were determined with ELISA before and after operation.
Results:
The serum contents of VEGF and bFGF before operation were significantly higher than that in control group ( P < 0.01). The serum contents of VEGF and bFGF after operation descreased significantly but were significantly higher than that in control group(P<0. 01). The serum contents of VEGF and bFGF before operation were positively related to the size of primarily tumor, Enneking type and tumor differentiation(P<0.05). The serum contents of VEGF and bFGF before and after operation were different significantly between recurrence and metastasis positive group with recurrence and metastasis negative group ( P < 0. 01). The Cox proportional hazards model showed that the serum contents of VEGF and bFGF before and after operation were an independent factor of the recurrence and metastasis for osteosar- coma patients after operative ( P <0. 01).
Conclusion:
The serum contents of VEGF and bFGF before and after operation can offer valuable assessments in evaluation of progression and metastasis prognosis.
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