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Updated: May 24, 2026

Continuous Flow Chemistry: Reaction of Diphenyldiazomethane with p-Nitrobenzoic Acid
Published on: November 15, 2017
[The impact of N, N-dimethylacetamide on the health of workers]
Yan-yan Lu1, Hao Wu, Hong-fang Tang
1Institute of Hygiene, Zhejiang Academy of Medical Sciences, Hangzhou, 310013, China.
Objective:
To explore the hepatic toxicity and the exposure biomarkers of N, N-Dimethylacetamide.
Methods:
One hundred forty five objects were chosen by stratified random sampling method. The investigation was performed using questionnaire and physical examination. The air concentrations of DMAC in the workshops were monitored. The urine samples were collected and analyzed after work everyday or at the weekend. The correlation between the air concentrations of DMAC in the workshops and the concentrations of urinary NMAC wee analyzed by regression.
Results:
The air concentration of DMAC in the spinning workshop was higher than others. The morbidity of abnormal hepatic function was 12.4%, 61.1% of workers with abnormal hepatic function appeared in one year after exposure to DMAC in the workshops ( r=0.44, P<0.01).
Conclusion:
The abnormal heptic function was found in workers exposed to DMAC for short period. The concentration of urinary NMAC can serve as the exposure biomarker of DMAC.
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