Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Anthelminthic Agents01:15

Anthelminthic Agents

Anthelmintic drugs differ significantly from antiparasitic therapies targeting protozoa, primarily due to differences in parasite biology. Whereas most protozoal treatments act on proliferating cells, anthelmintics are typically directed against mature, nonproliferative helminths. The therapeutic approach considers the helminth's reliance on neuromuscular coordination, glucose metabolism, and microtubular integrity for survival, reproduction, and localization within the host. Most anthelmintics...
Drugs for Treatment of Diarrhea-Predominant IBS01:17

Drugs for Treatment of Diarrhea-Predominant IBS

Diarrhea-predominant irritable bowel syndrome (IBS-D) is a subtype of IBS characterized primarily by frequent, loose, or watery stools, abdominal pain, and abdominal discomfort. Therapeutic approaches to managing IBS-D include dietary changes, stress management techniques, and pharmaceutical interventions.
Two specific drugs used in the treatment are alosetron (Lotronex) and eluxadoline (Viberzi). Alosetron, a 5-HT3 antagonist, works by slowing the movement of stools in the gut, reducing bowel...
Drugs Affecting GI Tract Motility: Antimicrobials as Antidiarrheal Agents01:18

Drugs Affecting GI Tract Motility: Antimicrobials as Antidiarrheal Agents

Acute diarrhea, a common gastrointestinal disturbance, is characterized by the rapid evacuation of fluid stools, leading to an excessive weight in fluid. This condition typically arises from disorders affecting intestinal water and electrolyte transport. It can be triggered by an increased osmotic load within the intestine, excessive secretion of electrolytes and water, mucosal exudation of protein and fluid, or altered intestinal motility. The primary risks of acute diarrhea are dehydration...
Antifungal Agents01:15

Antifungal Agents

Amphotericin B is a broad-spectrum antifungal agent that exploits structural differences between fungal and mammalian cell membranes. Its amphipathic structure—featuring a hydrophobic polyene-lactone ring and a hydrophilic region containing mycosamine and carboxylic acid groups—enables selective binding to ergosterol, a sterol predominantly found in fungal plasma membranes. This selective interaction underlies the drug’s antifungal activity, although weak binding to cholesterol contributes to...
Drugs Affecting GI Tract Motility: Adsorbents as Antidiarrheal Agents01:20

Drugs Affecting GI Tract Motility: Adsorbents as Antidiarrheal Agents

Diarrhea is characterized by the occurrence of frequent, watery bowel movements. Various factors can trigger diarrhea, including viral or bacterial infections, foodborne illnesses, side effects from certain medications, and underlying digestive disorders. If not adequately managed, diarrhea can lead to complications such as dehydration, electrolyte imbalances, and nutrient deficiencies. Severe diarrhea can lead to significant weight loss, malnutrition, and weakened immune function.
Adsorbents...
Drugs Affecting GI Tract Motility: Other Laxatives01:20

Drugs Affecting GI Tract Motility: Other Laxatives

Laxatives are primarily used to alleviate constipation, a common gastrointestinal disorder characterized by infrequent bowel movements and difficulty passing stools. They work by various mechanisms to increase the volume or frequency of bowel movements. The primary modes of action of laxatives include increasing stool bulk, softening the stool, stimulating intestinal motility, and osmotically drawing water into the intestines.
Osmotic or saline laxatives, like magnesium hydroxide or milk of...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Pheochromocytoma during pregnancy: laparoscopic and conventional surgical treatment of two cases.

Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association·2004
Same author

Exclusion of an extracolonic disease modifier locus on chromosome 1p33-36 in a large Swiss familial adenomatous polyposis kindred.

European journal of human genetics : EJHG·2004
Same author

Evidence for subthermal rotational populations in stored molecular ions through state-dependent dissociative recombination.

Physical review letters·2003
Same author

Improved test of time dilation in special relativity.

Physical review letters·2003
Same author

[Doppler sonographic estimation of normal values for flow velocity and resistance indices in renal arteries of healthy infants].

Ultraschall in der Medizin (Stuttgart, Germany : 1980)·2003
Same author

[Pediatric drugs at the European level].

Archives de pediatrie : organe officiel de la Societe francaise de pediatrie·2003
Same journal

[Physiopathology of chronic arthritis following chikungunya infection in man].

Medecine tropicale : revue du Corps de sante colonial·2012
Same journal

[Judicial or administrative settlement of medical malpractice claims. Update on medical liability].

Medecine tropicale : revue du Corps de sante colonial·2012
Same journal

[Chikungunya epidemic in 2005-2006: questions from occupational health professionals].

Medecine tropicale : revue du Corps de sante colonial·2012
Same journal

[Administrative issues linked to health insurance coverage of chronic post-chikungunya rheumatism].

Medecine tropicale : revue du Corps de sante colonial·2012
Same journal

[Coverage of the chikungunya epidemic on Reunion Island in 2006 by the French healthcare system].

Medecine tropicale : revue du Corps de sante colonial·2012
Same journal

[Five-year outcome of mother-to-child transmission of chikungunya virus].

Medecine tropicale : revue du Corps de sante colonial·2012
See all related articles

Related Experiment Video

Updated: May 24, 2026

Reduced Itraconazole Concentration and Durations Are Successful in Treating Batrachochytrium dendrobatidis Infection in Amphibians
06:49

Reduced Itraconazole Concentration and Durations Are Successful in Treating Batrachochytrium dendrobatidis Infection in Amphibians

Published on: March 14, 2014

[Triclabendazole].

C Boulliat1, A Wolf, K Gaillard

  • 1Service de Pharmacie Hospitalière, Marseille, France.

Medecine Tropicale : Revue Du Corps De Sante Colonial
|February 29, 2012
PubMed
Summary
This summary is machine-generated.

Triclabendazole effectively treats human fascioliasis, but resistance is growing. New treatments, like artesunate, are under investigation to combat this widespread parasitic disease.

More Related Videos

Ookluc: A Plasmodium berghei Line for Identifying Transmission-blocking Compounds
07:14

Ookluc: A Plasmodium berghei Line for Identifying Transmission-blocking Compounds

Published on: July 11, 2025

In Vitro Drug Screening Against All Life Cycle Stages of Trypanosoma cruzi Using Parasites Expressing β-galactosidase
08:48

In Vitro Drug Screening Against All Life Cycle Stages of Trypanosoma cruzi Using Parasites Expressing β-galactosidase

Published on: November 5, 2021

Related Experiment Videos

Last Updated: May 24, 2026

Reduced Itraconazole Concentration and Durations Are Successful in Treating Batrachochytrium dendrobatidis Infection in Amphibians
06:49

Reduced Itraconazole Concentration and Durations Are Successful in Treating Batrachochytrium dendrobatidis Infection in Amphibians

Published on: March 14, 2014

Ookluc: A Plasmodium berghei Line for Identifying Transmission-blocking Compounds
07:14

Ookluc: A Plasmodium berghei Line for Identifying Transmission-blocking Compounds

Published on: July 11, 2025

In Vitro Drug Screening Against All Life Cycle Stages of Trypanosoma cruzi Using Parasites Expressing β-galactosidase
08:48

In Vitro Drug Screening Against All Life Cycle Stages of Trypanosoma cruzi Using Parasites Expressing β-galactosidase

Published on: November 5, 2021

Area of Science:

  • Parasitology
  • Infectious Diseases
  • Drug Discovery

Background:

  • Human fascioliasis is a prevalent parasitic disease requiring effective treatment.
  • Triclabendazole is the primary therapy, generally safe and effective.
  • Widespread resistance to triclabendazole has emerged since the 1990s, necessitating alternative treatments.

Purpose of the Study:

  • To address the challenge of increasing triclabendazole resistance in human fascioliasis.
  • To explore alternative therapeutic agents for fascioliasis treatment.
  • To investigate the potential of artesunate as a novel treatment for human fascioliasis.

Main Methods:

  • Literature review on triclabendazole resistance patterns.
  • Analysis of current research on alternative fascioliasis treatments.
  • Evaluation of artesunate's efficacy and safety profile in preclinical or clinical studies (details not provided in abstract).

Main Results:

  • Triclabendazole resistance is a significant and growing concern.
  • Artesunate is identified as a promising candidate for new fascioliasis therapies.
  • Further research is ongoing to validate artesunate's effectiveness (details not provided in abstract).

Conclusions:

  • The emergence of triclabendazole resistance threatens effective fascioliasis treatment.
  • Artesunate shows potential as a valuable alternative or adjunct therapy.
  • Continued research and development are crucial for new anti-parasitic drugs.