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Related Concept Videos

Positron Emission Tomography01:29

Positron Emission Tomography

Positron emission tomography (PET) is a medical imaging technique involving radiopharmaceuticals — substances that emit short-lived radiation. Although the first PET scanner was introduced in 1961, it took 15 more years before radiopharmaceuticals were combined with the technique and revolutionized its potential.
One of the main requirements of a PET scan is a positron-emitting radioisotope, which is produced in a cyclotron and then attached to a substance used by the part of the body being...
Imaging Studies II: Positron Emission Tomography and Scintigraphy01:25

Imaging Studies II: Positron Emission Tomography and Scintigraphy

Positron Emission Tomography (PET) is a medical imaging technique that provides crucial insights into the body's physiological functions at a molecular level. It is an indispensable resource for diagnosing, staging, and monitoring various illnesses, notably cancer, neurological disorders, and cardiovascular conditions.
Fundamental Principles of PET

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Semi-quantitative Assessment Using [18F]FDG Tracer in Patients with Severe Brain Injury
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Brain FDG-PET changes in ALS and ALS-FTD.

Dimitri Renard1, Laurent Collombier, Giovanni Castelnovo

  • 1Department of Neurology, CHU Nimes, Hôpital Caremeau, 30029 Nimes Cedex 4, France. dimitrirenard@hotmail.com

Acta Neurologica Belgica
|February 29, 2012
PubMed
Summary

Fluorodeoxyglucose-positron emission tomography (FDG-PET) reveals more widespread frontal and temporal hypometabolism in Amyotrophic Lateral Sclerosis (ALS) than previously known. The anterolateral frontal lobe remains relatively preserved in ALS patients.

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Radiotracer Administration for High Temporal Resolution Positron Emission Tomography of the Human Brain: Application to FDG-fPET
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Radiotracer Administration for High Temporal Resolution Positron Emission Tomography of the Human Brain: Application to FDG-fPET

Published on: October 22, 2019

Area of Science:

  • Neurology
  • Neuroimaging
  • Metabolic Brain Imaging

Background:

  • FDG-PET in Amyotrophic Lateral Sclerosis (ALS) typically shows motor cortex hypometabolism, often with diffuse cortical involvement in prefrontal, premotor, and insular areas.
  • Amyotrophic Lateral Sclerosis with Frontotemporal Dementia (ALS-FTD) presents with severe diffuse frontal hypometabolism and extensive temporal hypometabolism.

Purpose of the Study:

  • To analyze FDG-PET findings in patients with ALS and ALS-FTD.
  • To identify and characterize patterns of cerebral metabolic changes in these neurodegenerative conditions.

Main Methods:

  • Analysis of FDG-PET scans.
  • Study included 6 patients with ALS and 4 patients with ALS-FTD.

Main Results:

  • ALS patients exhibited reduced FDG-PET metabolism in the medial frontal cortex, orbitofrontal cortex, and anterior temporal lobe, with the anterolateral frontal area being the best preserved.
  • ALS-FTD patients showed severe frontal and temporal hypometabolism, often with parietal involvement, and relatively preserved perirolandic metabolism.

Conclusions:

  • FDG-PET reveals more diffuse frontal and temporal hypometabolism in ALS than previously reported, highlighting the anterolateral frontal lobe as a relatively preserved region.
  • In ALS-FTD, severe frontal and temporal hypometabolism is associated with preserved perirolandic metabolism.