DetoxiProt: an integrated database for detoxification proteins.

Area of Science:

• Biochemistry
• Molecular Biology
• Toxicology

Background:

• Detoxification proteins are essential for eliminating harmful endogenous and exogenous substances, including toxins, medicines, and reactive oxygen species (ROS).
• These proteins play a critical role in maintaining physiological balance and are often induced by exposure to toxins or medicines.
• Integrating comprehensive data on detoxification proteins is vital for understanding their roles in health and disease.

Purpose of the Study:

• To develop a centralized and accessible resource for information on detoxification proteins.
• To facilitate the storage, retrieval, and analysis of features and functions of these proteins.

Main Methods:

• Development of the DetoxiProt database, a comprehensive resource for annotating detoxification proteins.
• Inclusion of detailed annotations covering sequences, structures, features, inducers, inhibitors, substrates, chromosomal locations, functional domains, and physiological-biochemical properties.
• Provision of pre-computed bioinformatics tools, including BLAST results, multiple sequence alignments, and evolutionary trees.

Main Results:

• The DetoxiProt database currently contains 5956 protein entries from 628 organisms.
• Extensive annotations and bioinformatics tools are available for each protein entry.
• A user-friendly web interface allows for efficient browsing and searching of detoxification protein data.

Conclusions:

• DetoxiProt offers an effective platform for accessing detoxification protein sequences and associated data.
• The database serves as a valuable resource for toxicologists, pharmacologists, and medicinal chemists.
• DetoxiProt is freely available online for research purposes.