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Targeted therapy of hepatocellular carcinoma: present and future

Stephen L Chan1, Winnie Yeo

  • 1State Key Laboratory in Oncology in South China, Sir YK Pao Center for Cancer, Department of Clinical Oncology, Hong Kong Cancer Institute and Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong. chanlam_stephen@cuhk.edu.hk

Journal of Gastroenterology and Hepatology
|February 29, 2012
PubMed

Insights

Targeted therapy shows promise for advanced hepatocellular carcinoma (HCC) by inhibiting molecular pathways. This review summarizes current clinical trials and future directions for novel HCC treatments.

Area of Science:

  • Hepatobiliary cancers
  • Molecular oncology
  • Clinical pharmacology

Background:

  • Sorafenib demonstrated efficacy in advanced hepatocellular carcinoma (HCC), shifting treatment paradigms.
  • HCC pathogenesis involves molecular defects and dysregulated pathways.
  • Targeted therapies aim to inhibit these aberrant pathways for improved clinical outcomes.

Purpose of the Study:

  • To review the current status of targeted therapy clinical development in HCC.
  • To focus on novel agents targeting angiogenesis, signal transduction, and epigenetic dysregulation.
  • To discuss lessons learned from completed trials and future perspectives.

Main Methods:

  • Literature review of clinical trials involving targeted agents in HCC.
  • Focus on agents targeting angiogenesis, signal transduction, and epigenetic mechanisms.
  • Analysis of outcomes from completed clinical trials.

Main Results:

  • An increasing number of targeted agents have been evaluated in HCC clinical settings.
  • Novel agents target key molecular pathways implicated in HCC progression.
  • Completed trials provide valuable insights into efficacy and safety.

Conclusions:

  • Targeted therapy represents a significant advancement in HCC treatment.
  • Understanding molecular pathways is crucial for developing effective therapies.
  • Future clinical trials should build upon current findings and explore novel strategies.

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